广西地区淋病患者淋病奈瑟菌对七种抗生素的耐药监测  

Surveillance of Neisseria Gonorrhoeae Resistant to Seven Antibiotics in Patients with Gonorrhea in Guangxi

作　　者：朱邦勇 李伟 甘泉 梁铭[2] 黄寅杰 李世慎 韦江平 陈怀忠 何绍 陈镇[4] 何基照 ZHU Bangyong;LI Wei;GAN Quan;LIANG Ming;HUANG Yinjie;LI Shishen;WEI Jiang-ping;CHEN Huaizhong;HE Shao;CHEN Zhen;HE Jizhao(Guangxi Institute of Dermatology,Nanning 530007,China;Affiliated Hospital of Guangxi Med-ical University,Nanning 530021,China;Yulin Skin Fisease Prevention and Treatment Hospital,Yu-lin 537000,China;d.Beihai People＇s ttospital,Beihai 536100,Chin;Guigang Skin Disease Hos-pital,Guigang 537100,China)

机构地区：[1]广西壮族自治区皮肤病防治研究所,广西南宁530007 [2]广西医科大学第一附属医院,广西南宁530021 [3]玉林市皮肤病防治医院,广西玉林537000 [4]北海市人民医院,广西北海536100 [5]贵港市皮肤病防治院,广西贵港537100

出　　处：《中国皮肤性病学杂志》2018年第9期1052-1056,共5页The Chinese Journal of Dermatovenereology

摘　　要：目的分析2013-2016年广西地区性病门诊淋病患者临床分离菌株对常见的七种抗生素的敏感性。方法从广西地区部分医疗机构淋病患者尿道或宫颈收集分泌物培养,通过纸片酸度定量法测定β内酰胺酶,琼脂稀释法测定青霉素、头孢曲松、头孢克肟、大观霉素、环丙沙星、阿奇霉素和四环素的最小抑菌浓度(MIC)。结果 2013-2016年从淋病患者中共收集临床分离菌株437株,未发现头孢曲松、头孢克肟和大观霉素的耐药菌株。有427株(97.71%)菌株和372株(85.13%)菌株分别对环丙沙星和青霉素耐药。耐四环素淋球菌(TRNG)菌株和β内酰胺酶阳性菌株(PPNG)阳性菌株分别为191株(43.71%)和145株(33.18%)。淋球菌对阿奇霉素耐药率保持1%~8%的较低水平。TRNG菌株和PPNG菌株阳性率均呈上升趋势。结论 2013-2016年期间来自广西地区性病门诊淋病患者的菌株对大观霉素、头孢曲松和头孢克肟敏感,适合作为本地区治疗淋病患者的一线药物;对阿奇霉素有一定耐药,对环丙沙星和青霉素高度耐药,TRNG菌株和PPNG菌株逐年上升,可能与青霉素和四环素的滥用或不规则使用有关。Objective To analyze the sensitivity of clinically isolated Neisseria gonorrhoeae（NG） to seven antibiotics in patients with gonorrhea who presented to STD clinic in Guangxi from 2013 to 2016Methods NG isolates were collected from the urethra or cervix uteri of patientsThe production of β-lactamase was detected by paper acidmetric testing,and minimum inhibitory concentrations（MICs） were determined by agar dilution method for peniclilin（P）,ceftriaxone（CRO）,cefixine（CTX）,sepctinomycin（SPT）,ciprofloxacin（CIP）,azithromycin（AZI） and tetracycline（TE）.Results A total of 437 NG isolates were collected from patients with gonorrhea from 2013 to 2016No isolate was resistant to CRO,CTX and SPTAmong above isolates,427（9771%） and 372（8513%）were resistant to CIP and P,respectivelyThe number of isolates with TRNG and PPNG was 191（4371%） and 145（3318%）,respectivelyThe low level of the resistance rate of staphylococcus was 1%~8%,and the positive rates of isolates with TRNG and PPNG increasedConclusionNG isolates from gonorrhea patients in Guaingxi from 2013 to 2016 sensitive to SPT,CRO and CTX,which were preferable as first-line drugs for gonorrhea,but they were certainly resistant to P and highly resistant to CIPThe positive rates of isolates with TRNG and PPNG are increasing year by year,and may be associated with the overuse or irregular use of penicillin and tetracycline.

关 键 词：淋球菌 耐药性 最小抑菌浓度 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]