Gentiopicroside, originated from Gentiana macrophylla Pall, possesses antiarthritic efficacy in adjuvant-induced arthritis rats  

作　　者：Ya-nan HUAN Lei-ming ZHANG Yong-ying LU Mei-ling WANG Yan-fei HAO Mao-jing ZHU Feng-hua FU 

机构地区：[1]School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China

出　　处：《中国药理学与毒理学杂志》2018年第4期287-287,共1页Chinese Journal of Pharmacology and Toxicology

摘　　要：OBJECTIVE This work aimed to investigate the anti-rheumatoid arthritic effect of gentio.picroside from Gentiana macrophylla Pall using an animal model of adjuvant induced arthritis.METH.ODS Adjuvant arthritis was induced in fifty SD male rats,which were randomly divided into five groups(n=10):control(0.5% CMC-Na) group,AIA(rats with CFA) group,dexamethasone(1 mg·kg^(-1)) group,gentiopicroside(50 mg·kg^(-1)) group,and gentiopicroside(100 mg·kg^(-1)) group.Rats were administered intragastrically with drugs or CMC-Na once a day for a period of 2 weeks.Paw swelling,arthritic index,histological changes were assessed to evaluate the anti-arthritic effect.Weight growth,spleen and thymus indexes were also investigated in.RESULTS Gentiopicroside at dose of 100 mg·kg^(-1) significantly inhibited the secondary paw swelling(P<0.05) and arthritis index(P<0.05),decreased synovial inflammatory infil.tration,synovial hyperplasia and bone erosion.Furthermore,gentiopicroside showed no immunosup.pressive adverse effects in body weight,index of spleen and thyums compared with dexamethasone administration(P<0.05,P<0.01).CONCLUSION Gentiopicroside possessed anti-arthritic efficacy in AIA rats without immunosuppressive effects.OBJECTIVE This work aimed to investigate the anti-rheumatoid arthritic effect of gentiopicroside from Gentiana macrophylla Pall using an animal model of adjuvant induced arthritis. METHODS Adjuvant arthritis was induced in fifty SD male rats, which were randomly divided into five groups （n=10）： control （0.5% CMC-Na） group, AIA （rats with CFA） group, dexamethasone （1 mg·kg-1） group, gentiopicroside （50 mg· kg-1） group, and gentiopicroside （100 mg· kg-1） group. Rats were administered intragastrically with drugs or CMC-Na once a day for a period of 2 weeks. Paw swelling, arthritic index, histological changes were assessed to evaluate the anti-arthritic effect. Weight growth, spleen and thymus indexes were also investigated in. RESULTS Gentiopicroside at dose of 100 mg· kg-1 significantly inhibited the secondary paw swelling （P〈0.05） and arthritis index （P〈0.05）, decreased synovial inflammatory infiltration, synovial hyperplasia and bone erosion. Furthermore, gentiopicroside showed no immunosuppressive adverse effects in body weight, index of spleen and thyums compared with dexamethasone administration （P〈0.05, P〈0.01）. CONCLUSION Gentiopicroside possessed anti-arthritic efficacy in AIA rats without immunosuppressive effects.

关 键 词：关节炎 风湿 治疗方法 中医 

分 类 号：R684.3[医药卫生—骨科学] R255.6[医药卫生—外科学]