Molecular Mechanism of Aconite-Ginger Muscle against Myocardial Ischemia Injury Based on Network Pharmacology  

作　　者：Jie WU Jing-yun XIANG Ya-feng YAN Zhi-yong LI Ming LI Bin WANG 

机构地区：[1]Shaanxi University of Chinese Medicine, Xianyang 712046, China [2]Minzu University of China, Beijing 100081, China

出　　处：《中国药理学与毒理学杂志》2018年第4期313-314,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：supported by Shaanxi Provincial Administration of Traditional Chinese Medicine project(JCPT007)

摘　　要：OBJECTIVE To use network pharmacology to predict and analyze the mechanism of Aconite-Ginger against myocardial ischemia.METHODS TCMSP was used to collect the active compounds of Aconite-Ginger and predict the targets of active compounds.At the same time,target sites of anti-myocardial ischemic injury drugs were collected using DisGeNET and CTD database,and then active compounds and target sites were compared.Analyze and screen out the targets of AconiteGinger anti-cardiac machine ischemia.GO,KEGG analysis and Aconite-Ginger drug molecule-target were performed on selected targets using MAS 3.0 and Cytoscape 3.3.0 software.RESULTS 27 common targets of Aconite-Ginger anti-ischemia ischemia and 63 signal pathways were predicted.CONCLUSION Aconite-Ginger mainly regulates calcium signal transduction,apoptosis and MAPK signaling pathway,which can also regulate through toll-like receptors,Fc epsilon RI and other signal pathways,so it is speculated that it may participate in regulation Apoptosis,inflammatory response,enhancement of myocardial function,etc.,thereby exerting an anti-ischemic effect.It laid a good foundation for further revealing its mechanism of action.OBJECTIVE To use network pharmacology to predict and analyze the mechanism of Aconite-Ginger against myocardial ischemia.METHODS TCMSP was used to collect the active compounds of Aconite-Ginger and predict the targets of active compounds.At the same time,target sites of anti-myocardial ischemic injury drugs were collected using DisGeNET and CTD database,and then active compounds and target sites were compared.Analyze and screen out the targets of AconiteGinger anti-cardiac machine ischemia.GO,KEGG analysis and Aconite-Ginger drug molecule-target were performed on selected targets using MAS 3.0 and Cytoscape 3.3.0 software.RESULTS 27 common targets of Aconite-Ginger anti-ischemia ischemia and 63 signal pathways were predicted.CONCLUSION Aconite-Ginger mainly regulates calcium signal transduction,apoptosis and MAPK signaling pathway,which can also regulate through toll-like receptors,Fc epsilon RI and other signal pathways,so it is speculated that it may participate in regulation Apoptosis,inflammatory response,enhancement of myocardial function,etc.,thereby exerting an anti-ischemic effect.It laid a good foundation for further revealing its mechanism of action.

关 键 词：药理学 心肌缺血 治疗方法 临床分析 

分 类 号：R285.5[医药卫生—中药学] R542.2[医药卫生—中医学]