伊班膦酸钠治疗恶性肿瘤骨转移痛的临床疗效  

The Clinical Study of Ibandronate Administration in the Treatment of Metastatic Bone Pain in the Patients of Malignant Cancer

作　　者：杨露露 邓文英 罗素霞 YANG Lu-lu;DENG Weng-ying;LUO Su-xia(Department of Digestive Medicine,the Cancer Hospital Affiliated to Zhengzhou University,Zhengzhou 450008,Henan Provinc)

机构地区：[1]郑州大学附属肿瘤医院消化内科,河南郑州450008

出　　处：《医学临床研究》2018年第8期1461-1464,共4页Journal of Clinical Research

基　　金：2016河南省科技开放合作项目（编号：162106000021）

摘　　要：[目的]探讨首剂负荷剂量及重复负荷剂量伊班膦酸钠治疗恶性肿瘤转移性骨痛的疗效和安全性.[方法]选取2012年至2018年本科收治40例恶性肿瘤骨转移患者,其中应用首剂负荷剂量组（A组）和重复负荷剂量组（B组）各20例.比较两组治疗前后的疼痛缓解率、生活质量KPS评分,止痛起效时间、止痛维持时间及不良反应.[结果]A组疼痛缓解有效率为55％（11/20）明显低于B组的90％（18/20）（P〈0.05）.治疗后A组生活质量评分（83.±10.89）分低于B组的（91.00±7.88）分,且差异有显著性（P〈0.05）.A组止痛起效时间和止痛维持时间分别为（3.60±0.50）d和（20.35±1.87）d,低于B组的均（2.70±0.40）d和（23.30±1.34）d,且差异有显著性（P〈0.05）.两组不良反应发生率相比较差异均无显著性（P〉0.05）.[结论]重复给予伊班膦酸钠负荷剂量止痛效果好,能明显迅速改善转移性骨痛,患者肾脏耐受性良好,不良反应轻,值得推广.[Objective]To observe the curative effect and safety of the first dose loading and the repeated loading dose of ibandronate in the treatment of metastatic bone pain of malignant tumors. [Methods]Forty patients with malignant bone metastases from 2012 to 2017 were selected, including 20 cases in the first dose loading group （group A） and 20 cases in the repetitive loading dose group （group B）. The pain score, quality of life KPS score, onset time of analgesia, duration of analgesia maintenance, and adverse reactions were observed and recorded before and after the application of ibandronate. [Results]The effective rate of pain relief was 55% （11/20） in the group A and 90% （18/20） in the group B （ P -0.05）. The scores of quality of life （QOL） in the group A （83±10.89） were lower than those in the group B （91.00±7.88）, and the difference was significant （ P 〈0.05）. The time of analgesic effect and maintenance were （3.60±0.50） days and （20.35±1.87） days in the group A, lower than those in the group B （2.70±0.40） days and （23.30±1.34） days, respectively （ P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （ P〉0.05）.[Conclusion] Repeated administration of ibandronate has a good analgesic effect and could improve metastatic bony pain rapidly, the kidney of the patients has good tolerance and mild adverse reaction, which is worth popularizing.

关 键 词：肿瘤/治疗 肿瘤转移 药用制剂 

分 类 号：R979.19[医药卫生—药品]