DNA甲基化与动脉粥样硬化  

DNA methylation and atherosclerosis

作　　者：王晓婷[1,2] 夏章勇 霍成举[3] 班茹 赵鑫 张柳英 张桂凤[1,2] 李莉 陆才胜[4] 刘博[5] Wang Xiaoting, Xia Zhangyong, Huo Chengju, Ban Ru, Zhao Xin, Zhang Liuying, Zhang Guifeng, Li Li, Lu Caisheng, Liu Bo(Graduate School of Taishan Medical University, Tai＇an 271000, China ; Department of Neurology, Liaocheng People＇s Hospital, the Research Center for Minimalty Invasive Therapeutic Engineering of Cardioeerebrovascular Diseases of Shandong Province, Liaocheng 252000, China; Department of Neurology, Liaocheng Third People＇s Hospital, Liaocheng 252000, China ; Dongchangfu District People＇s Hospital, Liaocheng 252002, China; Dong＇e County People＇s Hospital, Liaocheng 252201, China)

机构地区：[1]泰山医学院研究生部,泰安271000 [2]聊城市人民医院神经内科,山东省心脑血管病微创治疗工程技术研究中心,252000 [3]聊城市第三人民医院神经内科,252000 [4]聊城市东昌府区人民医院,252002 [5]聊城市东阿县人民医院神经内科,252201

出　　处：《国际脑血管病杂志》2018年第6期473-477,共5页International Journal of Cerebrovascular Diseases

基　　金：山东自然科学基金（ZR2015HL043）;山东省科技发展计划项目（2014GSF118106）;“十二五”国家科技支撑计划课题（2011BA108804）

摘　　要：动脉粥样硬化是环境与遗传因素相互作用导致的全身慢性炎性疾病.表观遗传修饰是连接环境因素与遗传因素的桥梁,DNA甲基化是一种重要的表观遗传修饰调控方式,可在转录前水平调节基因表达.已有研究表明,DNA甲基化在动脉粥样硬化的发生和发展过程中发挥着重要作用.因此,可通过天然或合成的DNA去甲基化酶使动脉粥样硬化相关DNA去甲基化,尤其是颈动脉粥样硬化相关DNA去甲基化,从而达到预防或治疗动脉粥样硬化性脑血管病的目的 .文章围绕DNA甲基化及其与动脉粥样硬化的关系以及DNA去甲基化治疗进行了综述.Atherosclerosis is a chronic systemic inflammatory disease caused by the interaction of environment and genetic factors. Epigenetic modification is a bridge between environmental factors and genetic factors. DNA methylation is an important regulatory mode of epigenetic modification, which can regulate gene expression at the pre-transcriptional level. Studies have shown that DNA methylation plays an important role in the occurrence and development process of atherosclerosis. Therefore, atherosclerosis-related DNA demethylation, especially carotid atherosclerosis-related DNA demethylation, can be achieved by natural or synthetic DNA demethylases, thereby achieving the purpose of preventing or treating atherosclerotic cerebrovascular disease. This article reviews DNA methylation and its relationship with atherosclerosis and DNA demethylation therapy.

关 键 词：动脉粥样硬化 DNA甲基化 后成说 遗传 

分 类 号：R543.5[医药卫生—心血管疾病]