某院耐碳青霉烯类革兰阴性杆菌检出率与药物消耗量的相关性分析  

Correlation Analysis between Detection Rate of Carbapenem Resistant Gram-negative Bacilli and Drug Consumption in A Hospital

作　　者：叶艮英 丁少波[1] 梁淑贞[1] 钟李青[1] YE Genying;DING Shaobo;LIANG Shuzhen;ZHONG Liqing(Department of Pharmacy,Dongguan City People＇s Hospital,Dongguan,Guangdong 523000,China)

机构地区：[1]东莞市人民医院药学部,广东东莞523000

出　　处：《今日药学》2018年第8期536-538,共3页Pharmacy Today

摘　　要：目的分析某院2016~2017年耐碳青霉烯类革兰阴性菌检出情况及其与抗菌药物消耗量的相关性。方法回顾分析2016~2017年某院耐碳青霉烯鲍曼不动杆菌、大肠埃希菌、铜绿假单胞菌检出率,分析其与抗耐碳青霉烯类革兰阴性杆菌药物用药量相关性。结果 2017年耐碳青霉烯鲍曼不动杆菌、大肠埃希菌、铜绿假单胞菌检出率显著高于2016年(76.64%vs.64.76%,1.89%vs.0.92%,36.81%vs.29.09%),且差异均有统计学意义(P<0.05)。2017年亚胺培南、美罗培南用药总量显著高于2016年[(7 899±81)g vs.(7 154±65)g,(3 855±73)g vs.(3 195±55)g],且差异均有统计学意义(P<0.05)。耐碳青霉烯鲍曼不动杆菌、大肠埃希菌、铜绿假单胞菌检出率与亚胺培南、美罗培南的消耗量呈正相关,且差异有统计学意义(P<0.05)。结论该院耐碳青霉烯革兰阴性杆菌检出率呈升高趋势,并与碳青霉烯类抗菌药物消耗量呈正相关。OBJECTIVE To analyze the correlation between the detection of carbapenem resistant gram-negative bacteria and the consumption of antimicrobial agents in a hospital in 2016 and 2017. METHODS The detection rates of Acinetobacter carpopenicilli,Escherichia coli and Pseudomonas aeruginosa in a hospital in 2016 and 2017 were analyzed retrospectively,and the correlation of drug dosage of carbapenem resistant gram-negative bacilli was analyzed. RESULTS In 2017,the detection rate of acinetobacter,Escherichia coli and Pseudomonas aeruginosa in 2017 was significantly higher than that in 2016（ 76.64% vs.64.761.89% vs.0.92%）,and the difference was statistically significant（ P0.05）. The the dosage of imipenem and meropenem was significantly higher in 2017 than in 2016[（ 7 899±81） g vs.（ 7 154±65） g,（ 3 855±73） g vs.（ 3 195±55） g],and the difference was statistically significant（ P0.05）. CONCLUSION There is a positive correlation between bacterial drug consumption and drug consumption.

关 键 词：耐碳青霉烯 革兰阴性杆菌 抗菌药物 药物消耗 

分 类 号：R969.3[医药卫生—药理学]