肿瘤标志物Cyfra21-1、NSE、CEA、CA125与肺癌骨转移的相关性  

Association of Tumor Markers Cyfra21-1,NSE,CEA and CA125 with Bone Metastasis in Lung Cancer

作　　者：未万东 WEI Wan-dong(Long chang Hospi tal,Sichuan 642150)

机构地区：[1]四川省隆昌县人民医院,642150

出　　处：《临床输血与检验》2018年第5期514-517,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：四川省卫生厅科研课题(No.120113)资助

摘　　要：目的观察肿瘤标志物Cyfra21-1、NSE、CEA、CA125与肺癌骨转移及转移程度之间的相关性。方法选择2016年1～12月至本院进行肺癌骨转移诊治的患者73例为观察组,同期在院诊治的无转移病灶肺癌患者106例为对照组。所有患者来诊后均行ECT及Cyfra21-1、NSE、CEA、CA125等肿瘤标志物检查,比较两组患者肿瘤标记物水平、肿瘤标记物阳性率,比较不同数量骨转移病灶和不同病理分型患者肿瘤标记物水平。结果观察组患者肿瘤标记物Cyfra21-1、NSE、CEA、CA125水平均明显高于对照组,差异有统计学意义(P<0.05);观察组患者肿瘤标记物Cyfra21-1、NSE、CEA、CA125单项检测阳性率与对照组的差异无统计学意义(P>0.05),但是联合检测的阳性率为80.82%,明显高于对照组38.68%,且差异有统计学意义(P<0.05);骨转移病灶<3个的患者肿瘤标记物Cyfra21-1、NSE、CEA、CA125水平明显低于转移灶≥3个的患者,且差异有统计学意义(P<0.05);观察组溶骨型转移、成骨型转移及混合型转移患者的肿瘤标记物Cyfra21-1、NSE、CEA、CA125水平的差异无统计学意义(P>0.05)。结论肿瘤标记物Cyfra21-1、NSE、CEA、CA125水平与肺癌骨转移具有相关性,骨转移患者上述指标水平和总体阳性率均明显升高,且各项肿瘤标记物水平随转移灶数目增加而增加,但与肺癌病理分型无关。因此可以成为肺癌骨转移患者病情变化和预后判断的参考依据。Objective To investigate the correlation of the tumor markers Cyfra21-1,NSE,CEA and CA125 in the patients of lung cancers with the bone metastasis（PLCM）. Methods Seventy-three patients with bone metastasis of lung cancers were selected in 2016 and 106 cases of lung cancers without bone metastasis were taken as control for examinations of ECT,Cyfra21-1,NSE,CEA,CA125.The levels of the markers were compared based on the focus number of bone metastasis and pathology types. Results The PLCM group had a significantly high level of Cyfra21-1,NSE,CEA,and CA125 compared with those without the metastasis（P〈0.05） but no difference of the positive rates was seen in any single marker test（P〈0.05）. The combined test of those markers,however,obviously increased the positive rates from 38.68% of the control to 80.82% of the PLCM（P〈0.05）. The incidence of bone metastasis went in parallel with high level of the serum markers（P〈0.05）while no statistic difference of the markers was noted among the patients with osteolytic and osteoblastic metastasis and mixed type of metastasis（P〈0.05）.Conclusion The increased level of Cyfra21-1,NSE,CEA,and CA125 is closely associated with bone metastasis and corresponds with the number of metastatic foci but not with the pathological types of lung cancers,suggesting that it might be useful for evaluation and prediction of bone metastasis in the patients with lung cancers.

关 键 词：肿瘤标志物 肺癌骨转移 ECT 相关性分型 

分 类 号：R446.11[医药卫生—诊断学] R734.2[医药卫生—临床医学]