海南紫海胆链霉菌HDa2中抗石斑鱼病原弧菌活性成分研究  

Study on Anti-Vibrio sp. Secondary Metabolites from Hainan Anthocidaris crassispina-associated Streptomyces sp. HDa2

作　　者：王蓉 陈傅晓 陈石泉 詹夏菲 冯全英 杨明秋 WANG Rong;CHEN Fu-xiao;CHEN Shi-quan;ZHAN Xia-fei;FENG Quan-ying;YANG Ming-qiu(Hainan Academy of Ocean and Fisheries Sciences,Haikou Hainan 57020)

机构地区：[1]海南省海洋与渔业科学院,海南海口570203

出　　处：《现代农业科技》2018年第18期220-220,222,共2页Modern Agricultural Science and Technology

摘　　要：运用多种层析方法从海南紫海胆肠道链霉菌HDa2中寻找抗石斑鱼病原弧菌的活性分子。结果获得4个雷锁辛类脂化合物,分别为1,3-二羟基-5-十五烷基苯、1,3-二羟基-5-异十五烷基苯、1,3-二羟基-5-十六烷基苯和1,3-二羟基-5-异十六烷基苯,其中1,3-二羟基-5-异十五烷基苯和1,3-二羟基-5-异十六烷基苯在10 mg/m L时具有抑菌活性,1,3-二羟基-5-异十六烷基苯的活性最强。本文首次从海洋链霉菌中发现该类分子,并且发现其具有抗石斑鱼病原弧菌的活性。Four phenolic lipids derivatives were isolated from the fermentation of the A nthociclaris crassispina-associated Streptomyces sp.HDa2 by chromatographic methods, including 1,3-two hydroxyl-5-fifteen alkylbenzene, 1,3-two hydroxyl-5-ISO fifteen alkylbenzene, 1,3-two hydroxyl- 5 -sixteen alkylbenzene, 1,3-two hydroxy-5-ISO sixteen alkylbenzene. 1,3-two hydroxyl-5-ISO fifteen alkylbenzene and 1,3 -two hydroxyl-5-ISO sixteen alkylbenzene showed inhibitory activity against grouper Vibrio sp. at 10 mg/mL,in which 1,3-two hydroxyl-5-ISO sixteen alkylbenzene had the stronger activity.The anti-Vibrio sp.acitivity of these compounds from Streptomyces sp. were reported here for the first time.

关 键 词：紫海胆 链霉菌 次生代谢产物 抗菌活性 

分 类 号：O629.9[理学—有机化学]