静脉滴注与持续泵入美罗培南治疗ICU重症肺炎的疗效  

Efficacy of intravenous drip infusion and continuous infusion of meropenem in the treatment of ICU severe pneumonia

作　　者：周康[1] 李爱光[1] ZHOU Kang;LI Ai-guang(Intensive Care Unit,Xi＇an Aerospace General Hospital,Xi＇an 710100,China)

机构地区：[1]西安航天总医院重症医学科,陕西西安710100

出　　处：《临床医学研究与实践》2018年第26期29-30,共2页Clinical Research and Practice

摘　　要：目的比较静脉滴注与持续泵入美罗培南治疗ICU重症肺炎的临床疗效。方法将我院ICU收治的重症肺炎患者80例按照药物输注方式分为试验组(n=40,静脉持续泵入美罗培南)和对照组(n=40,静脉滴注美罗培南),比较两组的临床治疗效果。结果治疗后,两组患者的体温、白细胞计数及肺部感染评分(CPIS)均显著改善,且试验组均优于对照组(P<0.05);试验组细菌总清除率明显高于对照组(P<0.05);两组不良发应总发生率比较,差异不显著(P>0.05),且均无严重不良反应发生。试验组的机械通气时间、入住ICU时间及药品相关费用均优于对照组(P<0.05)。结论与静脉滴入美罗培南比较,静脉持续泵入美罗培南治疗ICU重症肺炎的临床疗效更佳,抗感染抗菌作用显著,安全性高,且能够减轻患者经济负担。Objective To compare the clinical efficacy of intravenous drip infusion and continuous infusion of meropenem in the treatment of ICU severe pneumonia. Methods A total of 80 patients with severe pneumonia admitted to ICU in our hospital were divided into experimental group（n=40, intravenous continuous infusion of meropenem） and control group（n=40, intravenous drip infusion of meropenem） according to the medicine input methods. The clinical efficacies of the two groups were compared. Results After treatment, the body temperature, leucocyte count and clinical pulmonary infection scores（CPIS） of the two groups significantly improved, and those in the experimental group were better than the control group（P〈0.05）. The total bacterial clearance rate in the experimental group was significantly higher than that in the control group（P〈0.05）. There was no significant difference in the incidences of adverse reactions between the two groups（P〈0.05）, and no serious adverse reactions occurred in the two groups. The duration of mechanical ventilation, ICU stay time and medicine-related costs of the experimental group were better than those of the control group（P〈0.05）.Conclusion Compared with intravenous drip infusion of meropenem intravenous continuous infusion of meropenem has better clinical efficacy, significant anti-inflammatory and antibacterial effects in the treatment of ICU severe pneumonia,which has high safety and can reduce the economic burden of patients.

关 键 词：静脉滴注 静脉持续泵入 美罗培南 ICU重症肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]