普萘洛尔治疗婴幼儿血管瘤的临床效果  

Clinical effect of propranolol on infants with infantile hemangioma

作　　者：王晓馨[1] 宋颖[1] WANG Xiao-xin;SONG Ying(Dermatology Department,Baoji People＇s Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市人民医院皮肤科,陕西宝鸡721000

出　　处：《临床医学研究与实践》2018年第26期77-78,共2页Clinical Research and Practice

摘　　要：目的研究普萘洛尔治疗婴幼儿血管瘤的临床效果。方法选取我院2016年6月至2017年6月收治的80例血管瘤患儿为研究对象,随机分为对照组和观察组,各40例。观察组采用普萘洛尔治疗,对照组采用常规治疗,比较两组患儿的临床效果、血清凋亡因子水平变化及不良反应情况。结果观察组的治疗总有效率明显高于对照组(P<0.05);治疗后,两组患儿的Bax和Bcl-2水平均优于治疗前,且研究组优于对照组,差异显著(P<0.05)。观察组患儿不良反应总发生率显著低于对照组(P<0.05)。结论口服普萘洛尔能够调节婴幼血管瘤患儿血清凋亡因子平衡,提高临床效果,安全性高,值得临床推广与应用。Objective To study the clinical effect of propranolol in the treatment of infantile hemangiomas. Methods A total of 80 cases of children with hemangioma from June 2016 to June 2017 in our hospital were selected as the research objects and randomly divided into control group and observation group, with 40 cases in each group. The observation group used propranolol treatment, the control group was treated with routine therapy. The clinical efficacy, the levels of serum apoptotic factors and adverse reactions of the two groups were compared. Results The total treatment effective rate in the observation group was significantly higher than that in the control group（P〈0.05）. After treatment, the levels of Bax and Bcl-2 in the two groups were better than those before treatment, and those of the observation group were superior to the control group（P〈0.05）. The total incidence of adverse reactions in the observation group was significantly lower than that in the control group（P〈0.05）. Conclusion Oral propranolol can regulate the balance of serum apoptosis factor in infants hemangioma, improve the clinical effect and safety, which is worthy of clinical popularization and application.

关 键 词：普萘洛尔 婴幼儿血管瘤 凋亡 

分 类 号：R739.5[医药卫生—肿瘤]