供者NK细胞及其嵌合状态在异基因造血干细胞移植中的研究进展  

Research progress of donor NK cells and chimerism in allogeneic hematopoietic stem cell transplantation

作　　者：杨芳[1] 盛立霞[1] 欧阳桂芳[1] Yang Fang;Sheng Lixia;Ouyang Guifang(Department of Hematology,Ningbo Municipal First Hospital Affiliated to Ningbo University Medical School,Ningbo 315000,China)

机构地区：[1]宁波大学医学院附属宁波市第一医院血液科,315000

出　　处：《中华移植杂志（电子版）》2018年第2期91-96,共6页Chinese Journal of Transplantation(Electronic Edition)

基　　金：国家自然科学基金(81401321)

摘　　要：目前,异基因造血干细胞移植(allo-HSCT)已广泛应用于造血系统疾病的治疗,但移植术后也存在一系列并发症。NK细胞的运用为改善allo-HSCT受者预后带来希望,供者来源NK细胞通过其细胞膜上的杀伤细胞免疫球蛋白样受体与其配体错配发挥同种异体反应,该过程具有保留移植物抗白血病和减少移植物抗宿主病双重效应。NK细胞是allo-HSCT后受者体内最早重建的免疫细胞群,因此移植后供、受者NK细胞嵌合状态评估对预测疾病预后及指导干预治疗具有重要意义。基于NK细胞嵌合状态的供者NK细胞输注免疫干预疗法可改善疾病预后,在血液系统疾病治疗中表现出良好的应用前景。本文就近年来供者NK细胞及其嵌合状态在allo-HSCT中的研究进展作一综述。Allogeneic hematopoietic stem cell transplantation（ allo-HSCT） has been widely used for the treatment of hematopoietic diseases,nonetheless,major challenges persist,including a series of complications. The application of natural killer（ NK） cells brings hope for improving the prognosis of patients after allo-HSCT. Killer cell immunoglobulin-like receptors（ KIR） located on cytomembrane of donor NK cells and KIR-ligands mismatch plays a role in promoting the alloreactivity of NK cells,which maintains graft versus leukemia effects while reducing graft versus host disease. NK cells is the first immune cell subset to recover after allo-HSCT,so the monitoring of NK cells chimerism plays an significant role in predicting the prognosis of diseases and the intervention treatment.Furthermore,NK cells infusion based on chimerism is likely to improve the prognosis,which shows a broad application prospect in hematopoietic diseases. This article is to review the research progress of aforementioned aspects.

关 键 词：异基因造血干细胞移植 NK细胞 同种异体反应 嵌合状态 移植物抗宿主病 移植物排斥反应 

分 类 号：R457.7[医药卫生—治疗学]