艾曲泊帕治疗成人原发免疫性血小板减少症的近期疗效及不良反应的荟萃分析  

Meta analysis of short term efficacy and side effects of eltrombopag in the treatment of adult idiopathic thrombocytopenic purpura

作　　者：闫朝奇 冷青[1] 由国平 张丽君[3] Yan Chaoqi;Leng Qing;You Ouoping;Zhang Lijun(Department of Haernatologs,Central Hospital of Anshan City,Anshan 114000;Department of Haernatologs,Anshan Hospital Addicted to the First Affiliated Hospital of China Medical University,Anshan 114000;Department of Haematologs,First Affiliated Hospital of China Medical University,Shen yang 110000)

机构地区：[1]鞍山市中心医院血液科,辽宁鞍山114000 [2]中国医科大学附属第一医院鞍山医院血液科,辽宁鞍山114000 [3]中国医科大学附属第一医院血液科,辽宁沈阳110000

出　　处：《临床荟萃》2018年第9期800-804,共5页Clinical Focus

摘　　要：目的综合评价艾曲泊帕治疗成人原发免疫性血小板减少症(ITP)的近期疗效、出血好转情况与安全性。方法检索2018年4月前pubmed,万方数据库,维普数据库,CNKI,中国生物医学文献数据库,纳入艾曲泊帕治疗成人ITP的随机对照研究或单臂研究。评价纳入研究的方法学质量并提取数据后,采用R软件的meta程序包对结果进行合并分析。结果共纳入5个随机对照试验和2个单臂临床研究,包括633例成人ITP患者。艾曲泊帕治疗组总有效率68%,出血好转率65%,与安慰剂组比较,总有效率、出血好转率有明显差异,不良反应差异无统计学意义。结论艾曲泊帕治疗成人ITP疗效确切,不良反应低,可作为成人ITP治疗的新选择。Objective To evaluate the short term efficacy, bleeding improvement and safety of Ai Cooperpa in the treatment of adult idiol？athic thrombocytopenic purpura（ITP）. Methods Randomized controlled study or single arm study of eltrombopag for the treatment of adult ITP were collected from Pubmcd, Wanfang database, Vipu database, CNKI, Chinese biomedical literature database. The quality of the methodology used by the study was evaluated, the data was extracted, and R software recta package was used to analyze the results. Pubmed, Wanfang Database, Wipe Database, CNKI, and Chinese Biomedical Literature Database before April 2018 were retrieved for randomized controlled or single arm studies of atropine in the treatment of adult ITP. After evaluating the methodological quality of the included studies and extracting the data, R software recta package was used to merge and analyze the results. Results Altogether, 5 randomized controlled trials and 2 single arm clinical trials were included, including 633 adult ITP patients. The total effective rate of eltrombopag treatment was 68% and the rate of bleeding improved was 65%. Comparcd with the placebo group, the total effective rate and the rate of bleeding improvement were significantly different, and the adverse reaction was not statistically significant. Conclusion Eltrombopag has definite curative effect and low adverse reaction on the treatment of adult ITP. It is a new choice for adult ITP treatment.

关 键 词：血小板减少 艾曲泊帕 META分析 

分 类 号：R558.2[医药卫生—血液循环系统疾病]