脑白质高信号与认知功能障碍：基于FLAIR高信号的定量研究  

Quantitative Analysis on Correlation between Cognitive Impairment and Cerebral White Matter Hyperintensityon FLAIR Sequence

作　　者：叶娜[1] Wei Wen 王金芳[1,3] 石庆丽 李越秀[1] 陈红燕[5] Perminder Sachdev[2] 王拥军 张玉梅[1] YE Na;Wei Wen;WANG Jin-Fang;SHI Qing-Li;LI Yue-Xiu;CHEN Hong-Yan;Perminder Sachdev;WANG Yong-Jun;ZHANG Yu-Mei(Department of Neurology,Beijing Tiantan Hospital Capital Medical University;China National Clinical Research Center for Neurological Disease;Center of Stroke,Beijing Institute for Brain Disorder;Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease,Belling 100050,Chin;2Neuropsychiatrie Institute,Prince of Wales Hospital Randwick,New South Wales,Australi;School of Psychiatry,University of New South Wales,Campbell Town,NSW,2560,Australia;3Department of Neurology,General Hospital of the Yang Tze River ShippingoWuhan Brain Hospital Wuhan 430000,China,4Department of Neurology,Beijing Pinggu Hospital,Beijing 101299,China,5Department of Radiology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心、国家神经系统疾病临床医学研究中心、北京脑重大疾病研究院脑卒中研究所、脑血管病转化医学北京市重点实验室,北京100050 [2]Neuropsychiatric Institute,Prince of Wales Hospital,School of Psychiatry,University of New South Wales [3]长江航运总医院·武汉脑科医院神经内科 [4]北京市平谷区医院神经内科 [5]首都医科大学附属北京天坛医院放射科

出　　处：《中国卒中杂志》2018年第8期809-813,共5页Chinese Journal of Stroke

基　　金：国家自然科学基金(81371201);北京市医管局“扬帆计划”重点扶持项目;首都医科大学基础与临床合作重点项目(16JL03)

摘　　要：目的利用半自动化分析软件对脑白质疏松患者不同区域白质损伤进行定量,并对其与认知功能评分进行偏相关分析。方法 2011年1月-2017年1月在北京天坛医院进行健康体检的50～85岁社区"健康"人群63例,对其进行认知功能评价[简易精神状态量表(mini-mental state examination,MMSE)、蒙特利尔认知量表(Montreal cognitive assessment,Mo CA)]及影像学数据采集,基于液体衰减反转恢复序列定量计算全脑、侧脑室旁及深部皮层下脑白质受损体积,将认知功能评分与以上白质受损体积进行偏相关分析,探索白质受损在认知障碍发生发展过程中所起的作用。结果控制年龄、性别、文化程度后,全脑白质体积与MMSE评分、Mo CA评分有偏相关性(R’=-0.428,P=0.001)(R’=-0.539,P<0.001),尤其是侧脑室旁白质体积(R’=-0.427,P=0.001)(R’=-0.559,P<0.001),与深部皮层下白质也存在偏相关性(R’=-0.365,P=0.004)(R’=-0.447,P<0.001)。结论全脑、侧脑室旁、深部皮层下脑白质损伤体积增大,认知功能评分随之下降;MMSE评分、Mo CA评分与侧脑室旁白质损伤之间的相关性较深部皮层下白质损伤更大。Objective To analyze white matter hyperintensity（WMH） in different brain regions in patients with cerebral leukoaraiosis using semi-automatic quantitative analysis software, and analyze the partial correlation of WMH and cognitive impairment.Methods A total of 63 ‘healthy＇ community subjects（50-85 years） who had a physical examination in Beijing Tiantan hospital from January 2011 to January 2017 were included in this study. The cognitive function of all subjects were assessed using mini-mental state examination（MMSE） and Montreal cognitive assessment（MoCA）. We quantitatively analyzed the WMH in the whole brain, periventricular and deep cortex on fluid attenuated inversion recovery（FLAIR） sequence, which represented white matter lesion, and made a partial correlation analysis of the volume of white matter lesion and cognitive function score, to investigate the role of white matter lesion in the development of cognitive impairment.Results After adjusting for age, gender and education level, the volume of whole brain white matter lesion still had a partial correlation with MMSE and MoC A scores（R ＇=-0.428, P =0.001; R ＇=-0.539, P0.001, respectively）, and so did periventricular white matter lesion（R＇=-0.427, P=0.001; R＇=-0.559, P0.001, respectively） and deep cortex white matter lesion（R＇=-0.365, P=0.004; R＇=-0.447, P0.001, respectively）.Conclusions There is a positive correlation between cognitive impairment severity and cerebral white matter lesion volume, especially white matter lesion in periventricular region.

关 键 词：脑白质高信号 认知障碍 液体衰减反转恢复序列 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]