猪肺表面活性物质预防早产儿呼吸窘迫综合征的临床效果观察  

Clinical Effect of Porcine Pulmonary Surfactant on Preventing Premature Infant Respiratory Distress Syndrome

作　　者：郑方芳[1] 麦蕾[2] 江东[3] 周传新[1] ZHENG Fang-fang;MAI Lei;JIANG Dong(Department of Pediatrics,The Fifth Affliated Hospital of Zhongshan University,Zhuhai 519000,Guangdong Province,China)

机构地区：[1]中山大学附属第五医院儿科,广东珠海519000 [2]中山大学附属第五医院消化科,广东珠海519000 [3]中山大学附属第五医院泌尿外科,广东珠海519000

出　　处：《罕少疾病杂志》2018年第4期11-13,共3页Journal of Rare and Uncommon Diseases

基　　金：珠海市科技计划项目(20161027E030070)

摘　　要：目的探讨猪肺表面活性物质预防早产儿呼吸窘迫综合征的临床效果观察。方法选取我院2014年6月-2016年9月出生的早产新生儿100例,按照出生时间平均分为两组,对照组对新生儿不进行任何预防治疗,观察组对新生早产儿进行肺表面活性物质(猪肺磷脂注射液)预防,观察两组新生早产儿各项临床指标变化及并发症发生情况。结果观察组早产儿PaH_2、PaCO_2、PaO_2/FiO_2指标在治疗后12h后与对照组相比,差异明显,均具有统计学意义(P<0.05);观察组通气情况、吸氧天数、住院时间均较对照组效果好,差异具有统计学意义(P<0.05);观察组早产儿并发症发生率为8%;对照组并发症发生率为32%,两组并发症发生情况差异均有统计学意义(χ~2=10.981,P<0.05)。结论新生早产儿使用肺表面活性物质预防呼吸窘迫综合征效果显著,并发症机率小,适合于在临床中推广应用。Objective To study the clinical effect of porcine pulmonary surfactant on preventing premature infant respiratory distress syndrome. Methods From Jun. 2013 to Sep. 2013, a total of 100 premature infants in our hospital were taken as the clinical research objects, and they were divided into control group（50 cases） and observation group（50 cases） according to their birth time. None prevention was given to the control group, but the observation group was given porcine pulmonary surfactant（Poractant Alfa Injection）. The changes of clinical indexes and the occurrence of complications in the two groups were observed. Results 12 h after treatment, the difference was statistical significance between the two groups in clinical indexes as PaH2, PaCO2 and PaO2/FiO2（P〈0.05）, the ventilation, oxygen inhalation days and hospital stay in the observation group were better than those in the control group, and their differences were statistically significant（P〈0.05）, the complication rate in the observation group was 8% which was significantly lower than that in the control group 32%, and their difference was statistically significant（χ2=10.981,P〈0.05）. ConclusionPorcine pulmonary surfactant has significant effect on preventing premature infant respiratory distress syndrome, and less complication rate. Thus, it is worthy of promotion in clinic.

关 键 词：猪肺表面活性物质 预防 早产儿呼吸窘迫综合征 

分 类 号：R722.6[医药卫生—儿科]