HBV相关性疾病不同严重程度患者外周血CD27+B细胞百分率的变化及其临床意义  

Clinical Significance of Peripheral Blood CD27+B Cell Percentage in Patients with Different HBV-related Disease Progressions

作　　者：王晓红 WANG Xiao-hong(Department of Clinical Laboratory,Pingdingshan Shenma Medical Group General Hospital,Pingdingshan 467099,Henan Province,China)

机构地区：[1]河南平顶山市平煤神马医疗集团总医院检验科,河南平顶山467099

出　　处：《罕少疾病杂志》2018年第4期56-57,65,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨在HBV相关性疾病不同严重程度的患者其外周血中CD27^+B细胞百分率的变化情况以及在临床中代表的意义。方法选择2016年2月至2017年2月期间在我院就诊的20例慢性乙型肝炎患者、23例乙肝相关性肝硬化患者、21例乙肝相关性肝癌患者作为研究对象,同时取同时期的25例健康志愿者作为对照组,对比健康志愿者和患者之间的细胞免疫中CD27^+B细胞百分率、体液免疫中IgM、IgD的表达情况。结果在CD27^+B细胞百分率对比中,健康志愿者为(5.17±0.38)%,慢乙肝患者为(4.53±0.21)%,肝硬化患者为(2.23±0.12)%,肝癌患者仅为(0.55±0.04)%,发现三组患者的CD27^+B细胞百分率要明显低于对照组(P<0.05),同时随着疾病的严重程度,CD27^+B细胞百分率下降的比例也越高。在IgM、IgD的表达情况对比中,发现三组HBV相关性疾病患者中,其IgM、IgD水平的表达要明显上升并高于对照组(P<0.05),同时疾病程度越严重,IgM、IgD上升的幅度也越高。结论在HBV相关性疾病中,患者疾病程度越严重,其外周血中的CD27+B细胞比例越低,而IgM、IgD的表达水平越高,预示着CD27^+B细胞和此类患者有密切联系,可以通过对CD27^+B细胞水平的监测来评估患者机体免疫系统能力,为临床治疗提供指导意见。Objective To explore the clinical significance of peripheral blood CD27＋B cell percentage in patients with different HBV-related disease progressions. Methods 20 patients with chronic hepatitis B, 23 patients with hepatitis Bassociated liver cirrhosis and 21 patients with hepatitis B-related hepatocellular carcinoma treated from February 2016 to February 2017 in our hospital were selected. 25 healthy check-ups were selected as control group. The CD27~＋B cell percentage as well as IgM and IgD expression of humoral immunity for each group was compared. Results Based on the TCD27~＋B cell percentage, the healthy check-ups accounted for（5.17±0.38）%, the chronic hepatitis B patients for（4.53±0.21）%, hepatitis B-associated liver cirrhosis patients for（2.23±0.12）% and the hepatitis B-related hepatocellular carcinoma patients for（0.55±0.04）%, it was known that the CD27~＋B cell percentage for the HBV-related patients were significantly lower than control group（P〈0.05）, the severer the disease was, the lower the CD27~＋B cell percentage was; the expression of IgM and IgD for HBV-related patients were significantly higher than control group（P〈0.05）, the severer the disease was, the higher the IgM and IgD expression was. Conclusion With the severer HBV-related disease,the CD27~＋B cell percentage is lower while the Ig M and Ig D expression is higher, which it indicates the CD27~＋B cells have a close correlation with the HBV-related patients. The monitoring of CD27~＋B cell is used to evaluate the patient’s immune system and provide the treatment guidance in clinical practice.

关 键 词：HBV相关性疾病 严重程度 CD27+B细胞百分率 免疫 

分 类 号：R512.62[医药卫生—内科学]