复方竹叶石膏颗粒治疗慢性咽炎的临床效果观察  

Clinical Effectiveness of Compound Zhuye Shigao Granule in Treatment of Patients with Chronic Pharyngitis

作　　者：路军章[1] 王丽娟 孙志高[1] 樊金灼[1] LU Jun-zhang;WANG Li-juan;SUN Zhi-gao;FAN Jin-zhuo(Department of Traditional Chinese Medicine,Hainan Branch of General Hospital of PLA,Sanya,Hainan 572013,China;Beijing Branch of China Eastern Airlines Corporation,Beijing 100621,China)

机构地区：[1]解放军总医院海南分院中医科,海南三亚572013 [2]中国东方航空股份有限公司北京分公司,北京100621

出　　处：《解放军医药杂志》2018年第9期105-108,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：海南省重点研发计划(ZDYF2016122)

摘　　要：目的观察复方竹叶石膏颗粒治疗慢性咽炎的有效性与安全性。方法选取2016年6月—2017年7月就诊的气阴不足型慢性咽炎患者180例作为研究对象。按就诊顺序采用随机数字表法分为观察组和对照组,每组90例。观察组口服复方竹叶石膏颗粒,对照组口服安慰剂颗粒,共服药2周。分别于治疗前、治疗后1周和2周记录并比较两组的中医症状积分,比较两组的临床疗效、复发率以及不良反应情况。结果观察组脱落2例,剔除1例;对照组脱落3例,剔除1例。治疗后1周,观察组咽干、咽痛、咽痒、咽灼热感、咽异物感和咽后壁充血积分低于对照组(P<0.05)。治疗后2周,观察组各项中医症状积分均低于对照组(P<0.05)。观察组临床总有效率高于对照组(P<0.05),复发率低于对照组(P<0.05)。两组用药期间均未发生不良反应。结论复方竹叶石膏颗粒治疗气阴不足型慢性咽炎具有较好的临床效果,且安全性良好。Objective To observe effectiveness and safety of Compound Zhuye Shigao Granule in treatment of patients with chronic pharyngitis （CP）. Methods A total of 180 CP patients with deficiency of Qi and Yin admitted during June 2016 and July 2017 were divided into observation group and control group （ n =90 for each group） according to random digits table. Observation group was treated with Compound Zhuye Shigao Granule orally, while control group was given placebo granules orally, and administrations in two groups were continous for 2 weeks. Symptom scores of traditional Chinese medicine （TCM） were recorded and compared before and in 1 and 2 weeks after treatment, and clinical effectiveness, recurrence rate and incidence rate of adverse reactions were also compared in two groups. Results There were 2 patients with exfoliation, 1 patient with exclusion and hyperemia in posterior wall of pharynx in observation group and 3 patients with exfoliation and 1 patient with exclusion in control group. In 1 week after treatment, scores of dry pharynx, pharyngodynia, pharyngeal itch, pharyngeal burning sensation, foreign bodies sensation and hyperemia in posterior wall of pharynx in observation group were significantly lower than those in control group （ P 〈0.05）. In 2 weeks after treatment, scores of TCM symptoms in observation group were all lower than those in control group （ P 〈0.05）. In observation group, the total effective rate was significantly higher （ P 〈0.05）, while recurrence rate was significantly lower than those in control group （ P 〈0.05）. No adverse reaction was found during administration in two groups. Conclusion Compound Zhuye Shigao Granule may achieve good clinical effectiveness with safety in treatment of CP patients with deficiency of qi and yin.

关 键 词：咽炎 复方竹叶石膏颗粒 安慰剂 

分 类 号：R766.14[医药卫生—耳鼻咽喉科]