民航飞行员CagA阳性幽门螺杆菌感染与颈动脉粥样硬化的关系研究  

Relevance Between CagA-antibody-positive Helicobacter Pylori Infection and Carotid Atherosclerosis in Airline Pilots

作　　者：谢菲 陈红艳[1] 李谦[1] 陈刚 XIE Fei;CHEN Hongyan;LI Qian(Physical Examination and Appraisal Institute of Civil Aviation Medical Center of Civil Aviation Administration of China,Beijing,100123)

机构地区：[1]中国民用航空局民用航空医学中心民用航空人员体检鉴定所,北京100123 [2]民航总医院核医学科,北京100123

出　　处：《航空航天医学杂志》2018年第8期938-940,共3页Journal of Aerospace medicine

摘　　要：目的探讨民航飞行员细胞毒素相关基因蛋白A(cag A)抗体阳性幽门螺杆菌感染与颈动脉粥样硬化的关系。方法选取2012年3月-2016年10月在民航医学中心鉴定所体检的40岁及以上男性飞行员409例,采用免疫印迹法检测幽门螺杆菌(Hp)抗体谱,同时收集受检者高血压、糖尿病、冠状动脉粥样硬化等病史,测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBS)。根据Cag A状态可分为cag A抗体阳性组和cag A抗体阴性组,进行组间比较。采用Logistic回归分析颈动脉粥样硬化的危险因素。结果 Hp感染率为62.8%(257/409),Cag A抗体阳性率41.8%(171/409)。颈动脉粥样硬化组高血压、冠脉粥样硬化(狭窄)发病率高于无颈动脉粥样硬化组(P<0.05),两组间在年龄、收缩压、舒张压、甘油三脂存在统计学差异。Cag A抗体阳性组颈动脉粥样硬化发生率(27.49%)高于Cag A抗体阴性组(18.91%)(P<0.05)。Logistic回归分析示Cag A阳性幽门螺杆菌感染与颈动脉粥样硬化呈正相关(P=0.028)。结论在民航飞行员中Cag A阳性幽门螺杆菌感染与颈动脉粥样硬化呈正相关。Objective To investigate the correlation between cytotoxin-associated-gene A protein（ cag A）-antibody-positive helicobacter pylori（ Hp） infection and carotid atherosclerosis. Methods 409 male airline pilots were enrolled from March 2012 to October 2016 who taked part in physical examination in Institute of Civil Aviation Aircrew Medical Assessment of Civil Aviation Medical Center. Antibody pmfile of Hp was detected by immunoblotting technique. Serum levels of high density lipoprotein cholesterol（ HDL-C）,low density lipopmtein cholesterol（ LDL-C）,total cholesterol（ TC）,triglyceride（ TG） and fasting blood glucose（ FBS） were tested. The history of hypertension,diabetes and coronary atherosclerosis were recorded. The pilots were divided into Cag A-antibody-positive group and Cag A-antibody-negative group.Risk faetors of carotid atherosclerosis were analyzed with Logistic regression analysis. Results The Hp positive rate in 409 pilots was 62. 8%（ 257/409）,the Cag A-antibody-positive rate was 41. 8%（ 171/409）. Proportions of hypertension and coronary atherosclerosis in carotid atherosclerosis group were signficantly higher than those in non-carotid-atherosclerosis group（ P〈0. 05）,there were significant differences in age,systolic pressure,diastolic pressure and triglyceride between two groups. The proportion of carotid atherosclerosis in Cag A-antibody-positive group（ 27. 49%） was signficantly higher than those in Cag A-antibody-negative group（ 18. 91%）（ P〈0. 05）. Logistic Regression analysis showed that Cag A-antibody-positive Hp infection showed positive relevance with carotid atherosclerosis. Conclusions Cag A-antibody-positive Hp infection is positivelv associated with carotid atherosclerosis in airline pilot.

关 键 词：飞行员 颈动脉粥样硬化 幽门螺杆菌 细胞毒素相关基因蛋白A 

分 类 号：R817.9[医药卫生—影像医学与核医学]