中医药联合HAART干预艾滋病患者免疫重建不良的Meta分析  

Meta-analysis of Traditional Chinese Medicine Combined with HAART Intervention for Poor Immune Reconstitution in AIDS Patients

作　　者：唐蓓蓓 李子木 高海滨 罗龙江 吴茜茜 罗向群 岑丰先 姜枫[3] 唐友明[3] TANG Beibei;LI Zimu;GAO Haibin;LUO Longjiang;WU Xixi;LUO Xiangqun;CEN Fengxian;JIANG Feng;TANG Youming(Guangxi University of Chinese Medicine,Nanning Guangxi China 530001;TCM Hospital of Fangchenggang City,Fangchenggang Guangxi China 538000;Ruikang Hospital Affiliated to Guangxi University of,Nanning Guangxi China 530011)

机构地区：[1]广西中医药大学,广西南宁530001 [2]防城港市中医医院,广西防城港538000 [3]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《中医学报》2018年第8期1375-1379,共5页Acta Chinese Medicine

基　　金：国家自然科学基金项目(81460716;81660771);广西中医药科技专项项目(GZLC16-75);广西医疗卫生适宜技术研究与开发项目(S201308-02);广西高发传染病中西医结合转化医学重点实验室(培育基地)项目{桂科基字[2016]133号}

摘　　要：目的:系统性评价中药制剂联合高效抗反转录病毒疗法(highly active anti-retroviral therapy,HAART)治疗艾滋病患者免疫重建不良的效果。方法:计算机检索中国知网、维普数据库、万方数据库、Pubmed,搜集中药制剂联合HAART治疗艾滋病患者免疫重建不良随机对照试验(randomized controlled trials,RCT)文献,根据改良版Jadad量表对纳入文献进行质量评价,使用Rev Man5.3软件对纳入文献进行Meta分析。结果:共纳入5个RCT文献,涉及761例患者,Meta分析结果显示,中药制剂联合HAART治疗艾滋病患者的CD_4^+T细胞变化情况,治疗组优于对照组{MD=31.61,95%CI=[16.73,46.49]},其治疗组有效率高于对照组{OR=2.07,95%CI=[1.51,2.85]}。结论:中药制剂联合HAART治疗艾滋病患者免疫重建不良的疗效优于单用HAART。Objective： To systematically evaluate the effects of high-level Active Anti-Retroviral Therapy（ HAART） on AIDS patients with poor immune reconstitution. Methods： CNKI,VIP,Wanfang and Pub Med databases were searched,and the literature on drug preparations combined with HAART were used to treat randomized controlled trials（ RCT） of AIDS patients with immune reconstitution was obtained. According to the improved version of Jadad,the quality of the included literature was evaluated. Meta-analysis of the included literature was performed using Rev Man 5. 3 software. Results： A total of 5 RCTs were included in 761 patients. Meta-analysis showed that the changes of CD4~＋T cells in patients with AIDS treated with traditional Chinese medicine and HAART were significantly better than those in the control group（ MD = 31. 61,95% CI =[16. 73,46. 49]）,and that of the treatment group was more effective than that of the control group（ OR = 2. 07,95% CI =[1. 51,2. 85]）. Conclusion： The clinical efficacy of Chinese medicine combined with HAART is significantly better than that of HAART alone in treatment of AIDS patients with poor immune reconstitution.

关 键 词：艾滋病 HIV 免疫重建不良 高效抗反转录病毒疗法 中医药疗法 META分析 

分 类 号：R259.129.1[医药卫生—中西医结合]