二仙健骨方联合针灸疗法治疗强直性脊柱炎疗效观察  

Therapeutic Effect of Erxian Jiangu Prescription Combined with Acupuncture in Treatment of Ankylosing Spondylitis

作　　者：贾淑丽[1] 曹海利 高立录 薛愧玲[3] JIA Shuli;CAO Haili;GAO Lilu;XUE Kuiling(The Second People＇s Hospital of Kaifeng City,Kaifeng Henan China 475002;The Center Hospital of Hami City,Hami Xinjiang China 839000;Henan University Hospital,Kaifeng Henan China 475000)

机构地区：[1]开封市第二人民医院,河南开封475002 [2]哈密市中心医院,新疆哈密839000 [3]河南大学医院,河南开封475000

出　　处：《中医学报》2018年第8期1558-1562,共5页Acta Chinese Medicine

基　　金：国家中医药管理局全国名老中医药专家崔玉衡教授传承工作室建设项目[国中医药人教发(2014)20];2015年开封市科技局计划发展项目(1503007)

摘　　要：目的:观察二仙健骨方联合针灸疗法治疗强直性脊柱炎的临床疗效。方法:将60例强直性脊柱炎患者按随机数字表法分为观察组和对照组,每组30例。对照组给予西药常规治疗,观察组给予自拟二仙健骨方(仙茅9 g,淫羊藿15 g,肉桂8 g,肉苁蓉10 g,独活20 g,杜仲15 g,制乳香10 g,制没药10 g,党参15 g,茯苓20 g,当归15 g,炒白芍20 g,桑寄生20 g,秦艽15 g,牛膝20 g,川芎12 g,甘草10g。)配合针灸疗法治疗,主穴选大椎、脾俞、肾俞、腰俞、膏肓、命门穴,配穴取夹脊穴、足三里穴。两组患者均以3个月为1个疗程。观察两组患者的临床疗效、实验室指标改变情况。结果:治疗后两组患者的临床疗效比较,观察组临床控制6例(21.4%),显效12例(42.8%),有效8例(28.6%),无效2例(7.2%),有效率为92.8%;对照组临床控制3例(10.3%),显效6例(20.7%),有效12例(41.4%),无效8例(27.6%),有效率为72.4%。两组比较,差异有统计学意义(P<0.05)。两组患者晨僵时间、血红细胞沉降率(erythrocyte sedimentation rate,ESR)、超敏C-反应蛋白(C-reaction protein,CRP)、Schober试验、免疫球蛋白A(immunoglobulin A,Ig A)、强直性脊柱炎病情活动指标(bath ankylosing spondylitis disease activity index,BASDAI)、强直性脊柱炎功能指数(bath ankylosing spondylitis functional index,BASFI)、胸廓活动度、脊柱痛、指地距指标比较,差异均有统计学意义(P<0.05)。观察组不良反应发生率为7.14%明显低于对照组的51.7%,差异有统计学意义(P<0.05)。结论:二仙健骨方加减联合针刺治疗强直性脊柱炎疗效显著,且不良反应小。Objective： To observe the clinical efficacy of Erxian Jianu recipe in the treatment of ankylosing spondylitis with Kidney Yang Deficiency and Cold Syndrome. Methods： 60 patients with ankylosing spondylitis were divided into observation group and control group according to random number table,with 30 cases in each group. The control group was given conventional western medicine treatment. The observation group was given self-made Erxian Jiangu Prescription（ C. curcas 9 g,Epimedium sp. 15 g,Cinnamon 8 g,Cistanche deserticola 10 g,Duohuo 20 g,Eucommia ulmoides 15 g,frankincense 10 g,system myrrh 10 g,Codonopsis pilosula 15 g,Poria 20 g,Angelica 15 g,Stir-fried White Poria 20 g,Mulberry 20 g,Radix quinquefolius 15 g,Achyranthes 20 g,Rhizoma Chuanxiong 12 g,Licorice 10 g.） combined with acupuncture treatment. The main acupoints were Dazhui,Pishu,Shenshu,Yaoshu,Gaohuang and Mingmen,with auxiliary acupoints being Jiaji and Zusanli. Both groups were treated with 3 months as a course of treatment. The changes in clinical efficacy and laboratory indicators of the two groups of patients were observed. Results：After treatment,the clinical efficacy of the two groups of patients was compared with 6 cases（ 21. 4%） in the observation group,12 cases（ 42. 8%） markedly effective,8 cases（ 28. 6%） effective,2 cases ineffective,and the effective rate was 92. 8%; Clinical control in 3 cases（ 10. 3%）,markedly effective in 6 cases（ 20. 7%）,effective in 12 cases（ 41. 4）,invalid in 8 cases,the effective rate was 72. 4%. The difference between the two groups was statistically significant（ P〈0. 05）. Morning stiffness,Erythrocyte sedimentation rate（ ESR）,high-sensitivity C-reactive protein（ CRP）,Schober test,immunoglobulin A（ Ig A）,BASDAI,BASFI,thorax activity,and spinal pain（ VAS score） in both groups There was a statistically significant difference between the finger-toground distance indicators（ P〈0. 05）. The incidence of adverse reactions in the observation group was 7. 14%,whi

关 键 词：强直性脊柱炎 二仙健骨方 针刺疗法 中医药疗法 中西医结合 

分 类 号：R259.932.3[医药卫生—中西医结合]