体检女性血清铁蛋白与骨密度的关系  

The relationship between serum ferritin and bone density of female check-ups

作　　者：张迪晖[1] 黄泽鑫[1] 罗斌[1] ZHANG Dihui;HUANG Zexin;LUO Bin(Department of Orthopedics,Guangdong Province Traditional Chinese Medical Hospital,Guangdong Province,Guangzhou 510000,China)

机构地区：[1]广东省中医院骨科,广东广州510000

出　　处：《中国医药导报》2018年第25期75-78,共4页China Medical Herald

基　　金：广东省中医药管理局课题(20151228)

摘　　要：目的探讨体检女性血清铁蛋白(Fer)与骨密度(BMD)和骨代谢的关系。方法选择2017年2~10月于广东省中医院体检中心体检的女性志愿者104名,按照年龄分为高龄组(年龄≥50岁,n=67)和低龄组(年龄<50岁,n=37);按照绝经情况分为绝经组(n=58)和未绝经组(n=46);按照骨量分为骨量正常组(股骨颈和腰椎T值≥-1 SD,n=40)和骨量减低组(股骨颈和腰椎T值<-1 SD,n=64)。比较不同年龄和不同骨量受试者血清Fer、BMD及骨代谢指标水平[碱性磷酸酶(ALP)、Ⅰ型原胶原氨基端延长肽(P1NP)和β-降解产物(β-CTX)]的变化,同时分析月经对于血清Fer、BMD及骨代谢指标水平的影响,另外分析体检女性血清Fer水平与BMD及骨代谢指标水平的相关性。结果高龄组女性血清中Fer、ALP、P1NP及β-CTX水平明显高于低龄组,而髋部、腰椎第1~4节(L_(1~4))和总股骨的BMD水平显著低于低龄组,且差异均有统计学意义(P<0.05);与骨量减低组相比,骨量正常组血清Fer、ALP、P1NP及β-CTX水平明显降低,而髋部、L_(1~4)和总股骨的BMD水平显著升高,且差异均有统计学意义(P<0.05);绝经组血清中Fer、ALP、P1NP及β-CTX水平明显高于未绝经组,而髋部、L_(1~4)和总股骨的BMD水平显著低于未绝经组;体检女性血清Fer与髋部、L_(1~4)和总股骨的BMD水平呈负相关(r=-0.698、-0.714、-0.682,P<0.05),而与血清中ALP、P1NP及β-CTX水平呈正相关(r=0.732、0.725、0.619,P<0.05)。结论女性血清Fer水平受到年龄、月经的影响,同时与BMD及骨代谢指标联系密切,可以作为预测骨量下降的重要指标。Objective To explore the relationship between serum ferritin（Fer） and bone density（BMD）, bone metabolism in physical examination. Methods A total of 104 cases of female volunteers from February 2017 to October2017 in Physical Examination Center of Guangdong Province Traditional Chinese Medical Hospital were selected. According to the age, they were divided into elder group（age≥50, n = 67） and young group（age〈50, n = 37）. According to the menopausal status, they were divided into the postmenopausal group（n = 58） and the non-menopausal group（n =46）. According to the bone mass, they were divided into the normal bone mass group（femoral neck and lumbar T value≥-1 SD, n = 40） and the bone mass reduction group（femoral neck and lumbar T value〈-1 SD, n = 64）. The levels of serum Fer, BMD and bone metabolism index [alkaline phosphatase（ALP）, type Ⅰ collagen amino terminal extension of the peptide（P1NP） and β-degradation products（β-CTX）] of the volunteers with different age and different bone mass were compared, meanwhile the effect of menstruation on serum Fer, BMD and bone metabolism indices was analyzed. In addition, the correlation between serum Fer and the levels of BMD and bone metabolism index was analyzed.Results The levels of Fer, ALP, P1NP and β-CTX of the elder group were obviously higher than the young group,while the BMD of hip and L（1-4） and total femoral were significantly lower than the young group, and the differences were statistically significant（P 〈 0.05）. Compared with bone mass reduction group, the levels of Fer, ALP, P1NP and β-CTX of normal bone mass group significantly decreased, but the BMD of hip and L（1-4） and total femoral significantly increased, and the differences were statistically significant（P 〈 0.05）. The levels of Fer, ALP, P1NP and β-CTX of menopausal group were significantly higher than those of the non-menopausal group, while the BMD levels of the hip,L（1-4） and the total femur were significantly lower

关 键 词：女性 铁蛋白 骨密度 骨代谢 

分 类 号：R580[医药卫生—内分泌]