解毒凉血法联合恩替卡韦抗病毒治疗慢性乙型肝炎临床疗效及对患者炎症因子的影响研究  

Effect of detoxification and cooling blood combined with entecavir antiviral therapy on chronic hepatitis B and its effect on inflammatory cytokines

作　　者：王万娥 李晶[1] 李荣[1] 王治新 Wang Wan＇e;Li Jing;Li Rong(Fourth People＇s Hospital of Huai＇an in Jiangsu Province,Huainan 22300)

机构地区：[1]江苏省淮安市第四人民医院,淮安223002 [2]陕西省神木县医院,神木719300

出　　处：《陕西中医》2018年第10期1387-1389,共3页Shaanxi Journal of Traditional Chinese Medicine

摘　　要：目的:探讨解毒凉血法联合恩替卡韦抗病毒治疗慢性乙型肝炎患者的临床疗效,并观察其对炎症因子的影响。方法:选取慢性乙型肝炎患者82例,按照治疗方式分组,采取单用恩替卡韦抗病毒疗法42例(对照组),基于对照组加用解毒凉血法40例(观察组),比较两组临床疗效及炎症因子水平。结果:两组治疗前肝功能指标、炎症因子及HBeAg、HBV-DNA水平比较无显著性差异(P>0.05),治疗6个月后两组ALT、AST均明显低于本组治疗前,且观察组ALT、AST明显低于对照组;治疗后两组HBeAg、HBV-DNA水平均明显低于本组治疗前,且观察组HBeAg低于对照组;治疗后观察组TNF-α、IFN-γ、IL-6及IL-8均明显低于对照组与本组治疗前,比较有显著性差异(P<0.05)。结论:解毒凉血法联合抗病毒治疗慢性乙型肝炎临床疗效较好,可有效降低炎症因子水平,值得应用。Objective： To investigate the clinical efficacy of detoxification and cooling blood combined with antiviral therapy of entecavir in patients with chronic hepatitis B,and to observe their effects on inflammatory cytokines. Methods： 82 patients with chronic hepatitis B who were enrolled in this study. Twenty-four patients （control group） received entecavir anti-viral therapy alone and were treated with detoxification 40 cases of cooling blood method （observation group）,the clinical efficacy and the level of inflammatory cytokines in both groups were compared. Results：Before treatment,there was no significant difference in liver function indexes,inflammatory factors,HBeAg and HBV-DNA levels between the two groups （ P 〉0.05）. After 6 months of treatment,ALT and AST in both groups were significantly lower than before treatment The levels of HBeAg and HBV-DNA in the two groups were significantly lower than those in the control group before treatment,and the HBeAg in the observation group was lower than that in the control group. After treatment,the levels of TNF-α,IFN-γ,IL-6 and IL-8 were significantly lower than the control group and the group before treatment,there was a significant difference （ P 〈0.05）. Conclusion：detoxification and cooling blood combined with antiviral treatment of chronic hepatitis B has a good clinical efficacy,which can effectively reduce the level of inflammatory cytokines and is worth promoting.

关 键 词：乙型肝炎/中西医结合疗法 清热解毒剂/治疗应用 抗病毒药 

分 类 号：R512.62[医药卫生—内科学]