降脂片对非酒精性脂肪肝大鼠血脂和血清中ALT、AST、γ-GT水平的影响  

Effect of Hypolipidemic Tablets on Blood Lipids and the Levels of ALT,AST and γ-GT in Serum of Rats with Non-alcoholic Fatty Liver

作　　者：耿秀丽[1] 王华民[1] 孙海龙 郭君毅[1] 孙建华[1] 郝少君[1] 马俊杰[1] 张正臣[1] 

机构地区：[1]解放军第371中心医院,河南新乡453000

出　　处：《中国药师》2018年第9期1528-1530,共3页China Pharmacist

基　　金：河南省重大科技攻关项目(编号:132102310408);河南新乡市重点科技项目(编号:ZG14015)

摘　　要：目的:观察降脂片对大鼠非酒精性脂肪肝(NAFLD)的影响。方法:72只雄性大鼠随机分为空白组、模型组、阳性药物组(东宝肝泰片,7.5 g·kg^(-1))、降脂片高、中、低剂量组(15,7.5,3.75 g·kg^(-1))。造模1周后开始给药,空白组和模型组给予同体积生理盐水,持续4周。末次给药2 h后,腹主动脉取血,检测血清中三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C),以及丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰基转移酶(γ-GT)水平变化。结果:与模型组相比,东宝肝泰片、降脂片高、中剂量组ALT、AST、γ-GT、TG、TC、LDL-C水平均显著降低,HDL-C水平显著升高(P<0.05或P<0.01);降脂片低剂量组ALT、AST、TC、TG水平显著降低(P<0.05或P<0.01)。结论:降脂片对高脂饲料和灌胃高脂乳剂及腹腔注射低剂量CCl_4建立的大鼠脂肪肝动物模型有较好的干预作用。Objective： To investigate the effect of hypolipidemic tablets in rats with nonalcoholic fatty liver disease （NAFLD）. Methods ： A stochastic grouping method for 72 male rats were introduced including the blank group, the model group, the positive drug group （ Dongbao Gantai tablets, 7.5 g · kg^- 1 ） and hypolipidemic tablets groups （ 15, 7.5 and 3.75 g ·kg-1 ）. After the model was set up successfully, the corresponding drug was given one week later, and the blank group and the model group was given normal saline with the same volume for four weeks. Two hours later after the last drug administration, the blood samples were collected from abdomi- nal aorta to investigate the levels of ALT, TG, γ-GT, TC, HDL-C, LDL-C and AST. Results： Compared with the model group, both the positive drug group and hypolipidemic tablets groups （7.5 and 15 g · kg-1 ） markedly decreased the levels of ALT, AST, γ-GT, TG, TC and LDL-C as well as markedly increased the level of HDL-C （P 〈 0.05 or P 〈 0.01 ）. Hypolipidemic tablets group （3.75 g · kg-1 ） significantly decreased the levels of ALT, AST, TC and TG（P 〈 0.05 or P 〈 0.01 ）. Conclusion： Hypolipidemic tablets show promising intervention in rats with fatty liver induced by high fat feed, intragastric high fat emulsion and low dose CC14 via intrap- eritoneal injection.

关 键 词：降脂片 大鼠 非酒精性脂肪肝 血清 

分 类 号：R285.5[医药卫生—中药学]