不同碎石方法的临床效果对比及对氧化应激状态的影响  

Comparison of clinical effects of different lithotripsy methods and their effects on oxidative stress

作　　者：李金涛[1] 李金凤[1] 程川[1] LI Jin-tao;LI Jin-feng;CHENG Chuan(Affiliated Hospital of Taian Medical College,Taian 271000,China)

机构地区：[1]泰山医学院附属医院,山东泰安271000

出　　处：《泰山医学院学报》2018年第10期1094-1096,共3页Journal of Taishan Medical College

摘　　要：目的探究经皮肾镜碎石术和输尿管软镜碎石术治疗肾结石的临床疗效对比和对机体氧化应激状态的影响。方法选取2016年1月—2017年9月我院收治的100例肾结石患者,随机分为观察组和对照组,每组50例。观察组采取FURL治疗,对照组实施PCNL治疗。对比两组临床疗效,手术并发症及手术氧化应激状态。结果观察组相比于对照组手术所用时间短,术中出血量少,术后3 d内止痛药使用次数少,总住院天数短,差异有统计学意义(P<0.05);患者一期成功清除结石结果:观察组44例(88.0%),对照组46例(92.0%),两组差异无统计学意义(P<0.05);观察组与对照组术中均未出现梗阻、出血等并发症,观察组术后肾绞痛1例,血尿3例,手术并发症发病率为8.0%,对照组肾包膜下血肿2例,血尿2例,败血症2例,手术并发症发病率为12.0%,两组术后并发症的差异无统计学意义(P<0.05);氧化应激状态:术前与术后7d两组患者血清MDA、SOD和GSH-Px水平的差异无统计学意义(P>0.05);术后1d、3d观察组患者血清MDA水平低于对照组,血清SOD和GSH-Px水平高于对照组,差异有统计学意义(P<0.05)。结论 PCNL和FURL治疗肾结石在疗效及术后并发症方面没有区别,但FURL的手术损伤更小,对机体的氧化应激影响小,术后恢复更快,因此值得临床推广应用。Objective： To explore the percutaneous nephrolithotomy（ Percutaneous nephrolithotomy,PCNL） and flexible ureteroscope（ Flexible ureteroscopic lithotripsy,FURL） comparison of the effects of clinical curative effect of the treatment of kidney stones and oxidative stress. Methods： from January 2016 to September 2017 in our hospital 100 cases of renal calculi patients were randomly divided into the observation group and the control group,50 cases in each group. The observation group adopted the FURL treatment,the control group PCN L treatment. Compared the clinical efficacy of two groups,oxidative stress and complications of surgery. Results： in the observation group than the control group in short time of surgery,less bleeding,postoperative analgesic use within the 3 D number,total length of stay is short,the difference was statistically significant（ P〈 0. 05）; patients with a clear success results： the observation group of 44 cases of stones（ 88%）,the control group of 46 cases（ 92%）,there was no significant difference between the two groups（ P〈 0. 05）;the observation group and the control group showed no obstruction,bleeding complications,renal colic patients in the observation group of 1 cases,3 cases of hematuria,incidence of surgical complications 8%,2 cases of control group renal subcapsular hematoma,2 cases of hematuria,2 cases of septicemia,surgical morbidity rate was 12%,there was no significant difference of complications after operation in the two groups（ P〈 0. 05）; oxidative stress： preoperative and postoperative 7 d in two groups of patients with serum MDA,there were no significant differences between SOD and GSH-Px the level of 1 D（ P〉 0. 05）; after the operation,the 3 D level of serum MDA in observation group than in the control group,the serum levels of GSH-Px and SOD was higher than the control group,the difference was statistically significant（ P〈 0. 05）.Conclusion： PCNL and FURL in the treatment of kidney Stone has no difference in curative e

关 键 词：经皮肾镜碎石术 输尿管软镜碎石术 肾结石 疗效 氧化应激 

分 类 号：R69[医药卫生—泌尿科学]