原发性高血压病儿外周血中循环内皮细胞与内皮祖细胞的检测及意义  

COUNTING OF PERIPHERAL CIRCULATING ENDOTHELIAL CELLS AND ENDOTHELIAL PROGENITOR CELLS AND ITS SIGNIFICANCE IN CHILDREN WITH PRIMARY HYPERTENSION

作　　者：石琳[1] 张圆圆 林瑶[1] 刘杨[1] 张明明[1] 米杰[2] 崔小岱[2] 李镓 SHI Lin;ZHANG Yuanyuan;LIN Yao;LIU Yang;ZHANG Mingming;MI Jie;CUI Xiaodai;LI Jia(Department of Pediatric Cardiology,Children＇s Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院心血管内科,北京100020 [2]首都儿科研究所

出　　处：《精准医学杂志》2018年第4期320-323,共4页Journal of Precision Medicine

基　　金：首都临床特色应用研究项目(Z1211070010120-54);首都儿科研究所方向性引导基金项目(FX-15-02)

摘　　要：目的通过对健康儿童、高血压前期病儿、原发性高血压病儿外周血中循环内皮细胞(CECs)和内皮祖细胞(EPCs)的检测,探讨CECs及EPCs与原发性高血压儿童的血压水平及靶器官损害的关系。方法 2015年1月—2016年9月在我院确诊的原发性高血压病儿64例(高血压组)及高血压前期儿童30例(高血压前期组),同期健康体检的同龄健康儿童30例(健康儿童组)作为对照。高血压组根据血压水平分为高血压1期组和高血压2期组;根据是否存在靶器官损害分为靶器官损害组和无靶器官损害组。常规行CECs和EPCs数量测定;每6个月动态随访,监测上述指标。结果高血压前期组、高血压组外周血中CECs的数量均明显高于健康儿童组(P<0.05);高血压组与高血压前期组间比较差异无显著性(P>0.05)。高血压前期组、高血压组外周血中EPCs数量均明显低于健康儿童组(P<0.05);高血压组与高血压前期组间比较差异无显著性(P>0.05)。高血压1期组与高血压2期组外周血中CECs和EPCs数量比较,差异无显著性(P>0.05)。靶器官损害组与无靶器官损害组外周血中EPCs数量比较,差异有显著性(P<0.05)。结论原发性高血压病儿存在内皮损伤及内皮修复功能的损伤,靶器官损伤病儿的内皮损伤程度可能更重,血管修复能力也更差。Objective To explore the association of circulating endothelial cells （CECs） and endothelial progenitor cells （EPCs） with blood pressure and target organ damage in children with primary hypertension by counting peripheral CECs and EPCs in children with a healthy condition, children with prehypertension, and children with primary hypertension. Methods A total of 64 children with primary hypertension （HTN group） and 30 children with prehypertension （PHTN group） diagnosed in our hospital from January 2015 to September 2016, and 30 healthy children undergoing physical examinations in the same period （healthy group, as controls） were enrolled in the study. According to the levels of blood pressure, children in the HTN group were divided into stage 1 HTN group and stage 2 HTN group. According to the presence or absence of target organ damage （TOD）, children were divided into TOD group and non-target organ damage group （NTOD group）. Peripheral CECs and EPCs counts were routinely determined, and monitored in dynamic follow-ups performed every 6 months. Results The peripheral CECs counts in the PHTN and HTN groups were significantly higher than that in the healthy group （ P 〈0.05）; however, there was no significant difference between the PHTN and HTN groups （ P 〉0.05）. The peripheral EPCs counts in the PHTN and HTN groups were significantly lower than that in the healthy group （ P 〈0.05）; however, there was no significant difference between the PHTN and HTN groups （ P 〉0.05）. There was no significant difference in the peripheral CECs and EPCs counts between the stage 1 HTN and stage 2 HTN groups （ P 〉0.05）. There was a significant difference in the peripheral EPCs count between the TOD and NTOD groups （ P 〈 0.05）. Conclusion Endothelial injury and impaired endothelial repair capacity occur in children with primary hypertension, and children with TOD may suffer from a more serious endothelial injury as well as poorer vascular repair capacity.

关 键 词：高血压 高血压前期 循环内皮细胞 内皮祖细胞 儿童 

分 类 号：R725.441[医药卫生—儿科]