山东地区汉族女性ER β基因多态性与桥本病相关性研究  

Relationship of estrogen receptor-β gene polymorphism with female Hashimoto disease of the Han nationality in Shandong province

作　　者：张金华 佟爱华 柳林[2] 徐方江 于凤泉 ZHANG Jin-hua;TONG Ai-hua;LIU Lin(Department ofEndocrinology,Linyi Central Hospital,Linyi,Shandong 276400,China)

机构地区：[1]临沂市中心医院内分泌科,山东临沂276400 [2]潍坊市人民医院内分泌科,山东潍坊261041

出　　处：《实用医药杂志》2018年第8期733-735,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨雌激素β受体(estrogen receptor-β,ERβ)CA重复序列多态性与山东汉族女性桥本病(Hashimoto disease,HD)的关系。方法选择山东省100例汉族女性HD患者为病例组,100名健康女性为对照组。对人ERβ基因上游的短串联重复序列(short tandem repeat,STR)进行基因序列分析,观察ERβ的CA重复序列多态性基因型的分布频率。结果在两组(CA)_n等位基因的分布频率差异无统计学意义(P=0.870);两组(CA)_n构成比比较发现,病例组S型构成比(63%)大于对照组(51%),L型构成比(37%)小于对照组(49%)。病例组和对照组的CA重复次数构成比比较差异无统计学意义(P=0.087)。结论 ERβ基因CA重复序列多态性与HD的发病无相关关系。Objective To investigate the association of ER-β CA repeat sequence gene polymohism with female Hashimoto disease（HD） of the Han nationality in Shandong. Methods Totalled 100 female with HD of the Han nationality in Shandong province were selected respectively as case group and 100 healthy women as control group. Short tandem repeat（STR） in hypervariable region of the ER-β gene was sequenced. The distribution of the genotype was studied in case group and control group. Results There was no statistical difference between distributing frequencies of CA repeat sequence polymorphism in control and case group（P=0.870）;The S genotype rate was 63% in case group and 51% in control group respectively. The S and L genotypes frequency were compared between two groups and the difference had no significant significance（P=0.087）. Conclusion ACAn dinucleotide repeat sequence polymorphism is not associated with HD.

关 键 词：桥本病(慢性淋巴细胞性甲状腺炎) 雌激素β-受体(ER β) 基因多态现象 CA重复序列多态性 

分 类 号：R581[医药卫生—内分泌]