调强放疗联合腔内近距离放疗在晚期宫颈癌中的疗效评价  

Evaluation of Intensity Modulated Radiotherapy Combined with Intracavitary Brachytherapy in Treatment of Advanced Cervical Cancer

作　　者：杨永昆[1] 许万松[1] YANG Yongkun;XU Wansong(Department of Radiology,Taizhou People′s Hospital,Taizhou 225300,China)

机构地区：[1]泰州市人民医院放疗科,江苏泰州225300

出　　处：《医学综述》2018年第17期3525-3528,共4页Medical Recapitulate

摘　　要：目的评价调强放疗联合腔内近距离放疗应用于晚期宫颈癌治疗的有效性及安全性。方法回顾性分析2014年6月至2015年5月泰州市人民医院放疗科收治的88例晚期宫颈癌患者的临床资料,在常规化疗基础上,根据治疗方法不同将患者分为单纯腔内近距离放疗组(对照组)和调强放疗联合腔内近距离放疗组(研究组),各44例。比较两组患者近期治疗效果、1年内病死率以及治疗期间不良反应发生情况。结果研究组总有效率显著高于对照组[93.18%(41/44)比72.73%(32/44)](P<0.05)。研究组放射性肠炎、放射性膀胱炎、骨髓抑制的发生率均显著低于对照组[61.36%(27/44)比77.27%(34/44)、63.64%(28/44)比79.54%(35/44)、81.81%(36/44)比61.36%(27/44)](P<0.05)。研究组和对照组随访6个月、1年的病死率比较差异均无统计学意义[2.27%(1/44)比6.82%(3/44),4.65%(2/44)比15.9%(7/44)](P>0.05)。两组患者治疗前、随访6个月、1年的心电图检查、肝肾功能检查、影像学检查均未见明显异常。结论调强放疗联合腔内近距离放疗有助于提高晚期宫颈癌患者的近期疗效,减少放射性损伤,安全有效。Objective To evaluate the efficacy and safety of intensity modulated radiotherapy combined with intracavitary brachytherapy in treatment of advanced cervical cancer.Methods A total of 88 patients with advanced cervical cancer admitted to Taizhou People＇ s Hospital from Jun.2014 to May 2015 were retrospectively analyzed.Basing on the routine chemotherapy,the patients were divided into an intracavitary brachytherapy group（control group） and an intensity modulated radiotherapy combining intracavitary brachytherapy group（study group）,44 patients each.The short-term efficacy,mortality during the first year and adverse events were compared between the two groups.Results Compared with the control group,the study group had significantly higher effective rate[93.18%（41/44） vs 72.73%（32/44） ].There were 61.36%（27/44） and 77.27%（34/44） of radiation enterocolitis,63.64%（28/44） and 79.54%（35/44） of radiation cystitis,and81.81%（36/44） and 61.36%（27/44） of marrow depression in the study group and control group respectively,which indicated significantly less adverse reactions in the study group than in the control group.Moreover,the two groups showed comparable mortalities at 6 months and 12 months[2.27%（1/44） vs 6.82%（3/44）,4.65%（2/44） vs 15.9%（7/44） ].No abnormality of electrocardiogram and liver or renal function examination and imaging examination was detectable in the two groups before treatment,at 6-month treatment,12-month treatment.Conclusion Intensity modulated radiotherapy combining intracavitary brachytherapy is safe and effective for advanced cervical cancer with improved short-term effect and reduced radioactive damage.

关 键 词：晚期宫颈癌 腔内近距离放疗 调强放疗 

分 类 号：R737.3[医药卫生—肿瘤]