硒酵母对成年桥本甲状腺炎患者TPO-Ab和氧化应激水平的影响  

Effects of Selenium Yeast on Thyroid Peroxidase Antibody and Oxidative Stress in Adult Patients with Hashimoto's Thyroiditis

作　　者：何婉霞 张玲[1] 李兴梅[1] 郝尧[1] HE Wan-xia;ZHANG Ling;LI Xing-mei;HAO Yao(Department of Endocrinology,Yulin Second Hospital,Yulin,Shaanxi 719000,China)

机构地区：[1]榆林市第二医院内分泌科,陕西榆林719000

出　　处：《临床误诊误治》2018年第9期26-29,共4页Clinical Misdiagnosis & Mistherapy

基　　金：陕西省卫生厅科研基金项目(2012JM30579)

摘　　要：目的探讨硒酵母对成年桥本甲状腺炎患者甲状腺过氧化物酶抗体(TPO-Ab)和氧化应激水平的影响。方法选取我院2014年1月—2017年6月收治的106例桥本甲状腺炎伴甲状腺功能减退,根据不同治疗方案分为对照组(n=50)和观察组(n=56)。测定两组TPO-Ab和甲状腺球蛋白抗体(TG-Ab)效价,检测血清丙二醛(MDA)和超氧化物歧化酶(SOD)水平,记录谷胱甘肽过氧化物酶(GPx)活性及游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺素(TSH)水平,观察不良反应发生情况。结果与对照组比较,观察组治疗后TPO-Ab和TG-Ab效价及MDA水平均显著降低,SOD和GPx水平显著升高,差异有统计学意义(P<0.05);与本组治疗前比较,两组治疗后TPO-Ab和TG-Ab效价及MDA、TSH水平均下降,SOD、GPx、FT3、FT4水平升高,差异有统计学意义(P<0.05)。两组治疗过程中及治疗后均未出现严重不良反应。结论硒酵母治疗成年桥本甲状腺炎疗效显著,安全性高。Objective To investigate the effects of selenium yeast on thyroid peroxidase antibody （TPO-Ab） and oxidative stress in adult patients with Hashimoto＇s thyroiditis. Methods A total of 106 patients suffering Hashimoto＇s thyroiditis with hypothyroidism who were admitted to our hospital from January 2014 to June 2017 were enrolled and divided into control group （ n = 50） and observation group （ n =56） according to different treatment options. The titers of TPO-Ab and thyroglobulin antibodies （TG-Ab） were determined in both groups, and the serum levels of malondialdehyde （MDA） and superoxide dismutase （SOD） were detected. In addition, the glutathione peroxidase （GPx） activity and levels of free triiodothyronine （FT 3）, free thyroxine （FT 4） and thyroid-stimulating hormone （TSH） were recorded, and adverse reactions were observed. Results Compared with the control group, the titers of TPO-Ab and TG-Ab and the level of MDA in the observation group were significantly decreased, while the levels of SOD and GPx were significantly higher, and the difference was statistically significant （ P 〈0.05）. Compared with those before treatment, the titers of TPO-Ab and TG-Ab, and levels of MDA and TSh were increased, whereas SOD, GPx, FT 3, and FT 4 in the two groups were all decreased after treatment, and there was significant differences （ P 〈0.05）. No severe adverse reactions were observed in the two groups during treatment and after treatment. Conclusion Selenium yeast is effective and safe in the treatment of Hashimoto＇s thyroiditis in adult patients.

关 键 词：甲状腺炎 自身免疫性 桥本病 成年人 疗效比较研究 

分 类 号：R581.4[医药卫生—内分泌]