全髋关节置换术用于股骨颈骨折患者的临床疗效评价及对血清OPG、BGP、ALP、CRP、IL-6的影响  

Evaluation of the Clinical Efficacy of Total Hip Replacement in the Treatment Femoral Neck Fracture and the Effect on Serum OPG, BGP and ALP, CRP, IL-6 Levels

作　　者：王雷[1] 张浩沙强 郭瑞[1] 王翀[2] 吉喆[1] WANG Lei;ZHANG Hao;SHA Qiang;GUO Rui;WANG Chong;JI Zhe(Department of bone surgery,people＇s Hospital of Xinjiang autonomous region,Urumqi,Xinjiang,830000,China;Department of orthopedics,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,830000,China)

机构地区：[1]新疆维吾尔自治区人民医院骨科中心骨二科,新疆乌鲁木齐830000 [2]新疆医科大学第一附属医院骨科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2018年第15期2973-2976,共4页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2014211A060)

摘　　要：目的:分析全髋关节置换术用于股骨颈骨折患者的临床效果及对血清骨保护素(OPG)、骨钙素(BGP)、碱性磷酸酶(ALP)、C反应蛋白(CRP)、白细胞介素-6(IL-6)的影响。方法:选择我院2014年3月~2016年3月收治的102例股骨颈骨折患者,按抽签法分为对照组与研究组,每组各51例。对照组采用半髋关节置换术治疗,研究组采用全髋关节置换术治疗。比较两组的临床疗效,治疗前后Harris评分、血清OPG、BGP、ALP、CRP、IL-6水平的变化及术后并发症的发生情况。结果:治疗后,研究组的优良率显著高于对照组(P<0.05);两组Harris评分、血清OPG、BGP、ALP、CRP、IL-6水平均较治疗前显著上升,且研究组Harris评分显著高于对照组(P<0.05),而两组OPG、BGP、ALP、CRP、IL-6水平比较差异无统计学意义(P>0.05)。结论:全髋关节置换术用于股骨颈骨折的临床效果肯定,虽可引起血清OPG、BGP、ALP、CRP、IL-6水平上升,但未增加手术风险。Objective： To analyze the clinical efficacy of total hip replacement in the treatment of femoral neck fracture and the effect on serum osteoprotegerin（OPG）, osteocalcin（BGP）, alkaline phosphatase（ALP）, c-reactive protein（CRP） and interleukin 6（IL-6）levels. Methods： 102 cases of patients with femoral neck fracture from March 2014 to March 2016 were selected and divided into the control group and the research group according to the draw method with 51 cases in each group. The control group was treated with hemiarthroplasty, while the research group was treated with total hip arthroplasty. The curative effect, changes of Harris score, serum OPG, BGP and ALP, CRP, IL-6 levels before and after operation and the incidence of postoperative complications were compared between two groups. Results： After treatment, the excellent rate of research group was higher than that of control group（P〈0.05）; the Harris scores, serum OPG, BGP, ALP, CRP and IL-6 levels of both groups was all obviously decreased than those before treatment, the Harris score of research group was higher than that of the control group（P〈0.05）, no significant difference was found in the serum OPG, BGP,ALP, CRP and IL-6 levels between two groups（P〈0.05）. Conclusion： Total hip replacement was effective in the treatment of femoral neck fracture, although it could cause the increase of serum OPG, BGP and ALP, CRP, IL-6 levels, but it did not increase the risk of surgery.

关 键 词：股骨颈骨折 全髋关节置换术 临床效果 骨保护素 骨钙素 碱性磷酸酶 C反应蛋白 白细胞介素-6 

分 类 号：R683[医药卫生—骨科学] R687[医药卫生—外科学]