Kca3.1通道及其与多个系统疾病关联的研究进展  

Role of Kca3.1 channel and mechanisms in diseases

作　　者：郭姝瑾 李小惠[1] 左秋南 申永春[2] 文富强[2] GUO Shujin;LI Xiaohui;ZUO Qiunan;SHEN Yongchun;WEN Fuqiang(Sichuan Academy of Medical Sciences,Sichuan Provincial People＇s Hospital,Chengdu 610072,China;Divisions of Pulmonary Diseases,State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 620042,China)

机构地区：[1]四川省医学科学院.四川省人民医院,四川成都610072 [2]四川大学华西医院呼吸内科.人类疾病生物治疗国家重点实验室呼吸病学研究室,四川成都610041

出　　处：《西部医学》2018年第9期1390-1396,共7页Medical Journal of West China

基　　金：国家自然科学基金(31171103);中央高校基金(ZYGX2015J127)

摘　　要：Kca3.1通道是重要的钙激活钾离子通道,广泛分布于人体多种类型细胞(上皮细胞、内皮细胞、成纤维细胞、平滑肌细胞、免疫细胞等)并参与调控细胞增殖、迁移、凋亡等细胞活动。目前研究发现Kca3.1通道与恶性肿瘤、气道重塑、血管缩窄、肾纤维化、贫血等多种疾病密切相关。本文通过对Kca3.1通道相关文献的复习,从生物学特征、电生理特点、作用机制(细胞增殖、迁移、分化、凋亡)等方面对Kca3.1通道进行综述,进一步阐述Kca3.1通道参与调控多个系统疾病的发生发展,为之后进一步研究提供参考。Kca3.1 channel is an important Ca^2＋-Activated K＋ Channels which was expressed in various cells（epithelial cell,endothelial cell,fibroblast,smooth muscle cell,Immune cell,et al）.It has been found that Kca3.1 could regulate cell proliferation,migration and apoptosis.Many studies had already elucidated the association between the Kca3.1 and malignant tumors,airway remodeling,vascular stenosis,renal fibrosis,anemia and other diseases.The review summarized the biological and electrophysiological characteristics,the mechanisms（proliferation,migration,differentiation and apoptosis）of the channel.Furthermore,we will discuss systematically the role of Kca3.1 and regulations involved in multi-system diseases.

关 键 词：Kca3.1 离子通道 细胞增殖 细胞迁移 

分 类 号：Q591.7[生物学—生物化学]