加替沙星治疗泌尿系统感染的疗效及对血清PCT IL-2 IL-8的影响  

Influnce of Gatifloxacin on Urinary Tract Infection and Its Effect on Serum PCT IL-2 and IL-8

作　　者：王琦[1] 梁京津[2] WANG Qi(Xuanwu Hospital of Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院泌尿外科,北京100053 [2]北京大学第三医院感染疾病科,北京100191

出　　处：《河北医学》2018年第9期1540-1544,共5页Hebei Medicine

基　　金：北京市优秀人才培养资助项目;(编号:2011D003034000018)

摘　　要：目的:探讨加替沙星治疗泌尿系统感染的疗效及对血清降钙素原(PCT)、白细胞介素-2(IL-2)、白细胞介素-8(IL-8)的影响。方法:选择2016年6月至2017年12月收治的122例泌尿系统感染患者,按照简单随机数字表法分为对照组和研究组,每组61例。对照组予以左氧氟沙星治疗,研究组予以加替沙星治疗。比较两组临床疗效,症状缓解时间,血清PCT、IL-2及IL-8水平,及不良反应发生情况。结果:研究组总有效率高于对照组,比较有统计学差异(P<0.05)。研究组尿路疼痛、尿频及尿急缓解时间均少于对照组,比较有统计学差异(P<0.05)。治疗前,两组血清PCT、IL-2及IL-8水平比较无统计学差异(P>0.05);治疗后,两组血清PCT及IL-8水平均下降,IL-2水平明显上升,研究组变化幅度更明显,比较有统计学差异(P<0.05)。两组不良反应以皮疹、头晕及胃肠道不适为主,组间不良反应发生率比较无统计学差异(P>0.05)。结论:加替沙星治疗泌尿系统的疗效确切,能够调节血清PCT、IL-2及IL-8表达,减轻临床症状,可能为临床治疗的可靠方案。Objective： To explore the effect of gatifloxacin in treatment urinary tract infection and its effect on serum PCT,IL-2 and IL-8. Methods： 122 patients with urinary tract infection who received therapy from June 2016 to December 2017 in two hospitals,according to the simple random number table method,those patients were divided into the control group and the research group,61 cases in each group. control group was treated with levofloxacin,and the research group was treated with gatifloxacin. Then clinical efficacy,symptom relief time,the level of serum PCT,IL-2 and IL-8,and adverse reactions between two group was compared. Results： Total effective rate and bacterial clearance rate in research group was higher than that of the control group（ P〈0.05）. the urinary tract pain,urinary frequency,and urgency relief time in research group was lesser than those in the control group,and there were statistically significant differences（ P〈0.05）.Before treatment,serum PCT,IL-2 and IL-8 in two group was no statistically significant difference（ P〈0.05）. After treatment,the levels of serum PCT and IL-8 in two group was decreased,and the level of IL-2 was significantly increased,and the changes of the research group were more obvious,there are statistically significant differences（ P〈0.05）. adverse reactions in two group were mainly rash,dizziness and gastrointestinal discomfort,Adverse reaction rate in two group was no statistically significant（ P〈0. 05）. Conclusion：Effect of gatifloxacin in treatment urinary tract infection is sure,and can regulate the expression of serum PCT,IL-2 and IL-8,and reduce clinical symptoms,which may be a reliable solution for clinical treatment.

关 键 词：泌尿系统感染 加替沙星 降钙素原 白细胞介素-2 白细胞介素-8 

分 类 号：R691.3[医药卫生—泌尿科学]