过渡金属催化的基于季铵盐C—N键断裂的偶联反应研究进展  

Progress on Transition-Metal-Catalyzed Cross-Coupling Reactions of Ammonium Salts via C—N Bond Cleavage

作　　者：李刚 陈烨[1] 夏纪宝 Li Gang;Chen Ye;Xia Jibao(School Chemistry of Chemical Engineering,Guizhou University,Guiyang 550025;State Key Laboratory for Oxo Synthesis and Selective Oxidation,Suzhou Research Institute of LICP,Lanzhou Institute of Chemical Physics（LICP）,Chinese Academy of Sciences,Lanzhou 730000)

机构地区：[1]贵州大学化学与化工学院,贵阳550025 [2]中国科学院兰州化学物理研究所苏州研究院羰基合成与选择氧化国家重点实验室,兰州730000

出　　处：《有机化学》2018年第8期1949-1962,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21702212;21772208;21402089);江苏省自然科学基金(No.BK20161260)资助项目~~

摘　　要：含有碳-氮(C—N)键的胺类化合物广泛存在于天然产物、药物分子和功能材料之中.C—N键作为分布最广且相对惰性的化学键之一,通过对其选择性的断裂来构建新的碳-碳(C—C)或碳-杂(C—X)键在近年来逐渐发展为一种新的合成方法.季铵盐化合物易于从胺类化合物合成,发生C—N键断裂相对容易.综述了近年来以季铵盐为原料通过过渡金属催化的C—N键断裂实现的交叉偶联反应.Amines containing carbon-nitrogen（C—N） bonds are widely distributed in natural products, drug molecules and functional materials. C—N bonds are one of the most abundant and inert bonds in organic molecules. Selective cleavage of C—N bonds to construct carbon-carbon（C—C） and carbon-heteroatom（C—X） bonds represents a new synthetic method in organic synthesis. It is difficult for the direct cleavage of C—N bond. Ammonium salts are a series of stable compounds easily obtained from amines. The recent progress of transition-metal-catalyzed cross-coupling reactions via C—N bond cleavage using ammonium salts as starting materials is summerized.

关 键 词：过渡金属催化 季铵盐 交叉偶联反应 C—N键断裂 

分 类 号：O621.251[理学—有机化学]