对称四甲基六元瓜环与卡培他滨通过主客体作用构筑的超分子药物包结配合物（英文）  

Supramolecular Drug Inclusion Complex Constructed from Tetramethyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

作　　者：张智睿 阚京兰 冯华明 刘青云[4] 陶朱[3] 肖昕[3] Zhang Zhirui;Kan Jinglan;Tao Zhu;Feng Huaming;Liu Qingyun;Xiao Xin(Department of Pediatric,The Ninth People＇s Hospital of Chongqing,Chongqing 400700;College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014;Key Laboratory of Maerocyclic and Supramoleeular Chenmistry of Guizhou Province,Guiyang 550025;College of Chemistry and Environmental Engineering,Shandong University of Science and Technology,Qingdao 266590)

机构地区：[1]重庆第九人民医院儿童综合科,重庆400700 [2]山东师范大学学化学化工与材料科学学院,济南250014 [3]贵州大学贵州省大环化学及超分子化学重点实验室,贵阳550025 [4]山东科技大学化学与环境工程学院,青岛266590

出　　处：《有机化学》2018年第8期1972-1976,共5页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Science and Technology Fund of Guizhou Province(No.2016-1030);the Innovation Program for High-Level Talents of Guizhou Province(No.2016-5657);the Major Program for Creative Research Groups of Guizhou Provincial Education Department(No.2017-028)~~

摘　　要：使用了核磁共振波谱、基质辅助激光解吸电离飞行时间质谱、等温滴定量热和荧光光谱等表征手段考察了对称四甲基六元瓜环(TMeQ[6])与抗癌性药物分子卡培他滨(CAP)之间的主客体超分子作用,实验结果表明:CAP分子的烷基链部分进入到了瓜环的空腔内部,而其余的部分则处于瓜环的端口外侧.该结论为今后TMeQ[6]在医学领域上作为药物分子载体方面的应用提供了理论依据.A novel supramolecular host-guest complex of the anticancer drug capecitabine（CAP） with symmetrical α,α′,δ,δ′-tetramethyl-cucurbit[6]uril（TMeQ[6]） has been characterized using nuclear magnetic resonance spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetryand fluorescence spectroscopy analyses. The result revealed that the alkyl chain of CAP is located inside the cavities of TMeQ[6], whereas the other part of CAP remains outside the portal. Our results suggest that TMeQ[6] could be a promising candidate for use as an excipient in the pharmaceutical and medical research fields.

关 键 词：超分子 主客体 瓜环 卡培他滨 自组装 

分 类 号：O641.3[理学—物理化学] TQ460.1[理学—化学]