介孔分子筛MCM-41固载席夫碱与Cu(ClO_4)_2·6H_2O催化合成螺[吲哚-噻唑啉酮]衍生物  

Mesoporous MCM-41 Supported Schiff Base-Cu(ClO_4)_2·6H_2O Catalyzed Synthesis of Spiro[indole-thiazolidine] Derivatives

作　　者：侯亚东 庞海霞[1] 杨超[1] 惠永海[1,2] Hou Yadong;Pang Haixia;Yang Chao;Hui Yonghai(Key Laboratory of Oil ＆ Gas Fine Chemicals＇,Ministry of Education ＆ Xinjiang Uyghur Autonomous Region,College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046;School of Chemistry and Chemistry Engineering,Lingnan Normal University,Zhanjiang 524048)

机构地区：[1]新疆大学化学化工学院石油天然气精细化工教育部重点实验室,乌鲁木齐830046 [2]岭南师范学院化学化工学院,湛江524048

出　　处：《有机化学》2018年第8期2036-2044,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21362036;51564045)资助项目~~

摘　　要：利用介孔分子筛纳米反应器MCM-41@席夫碱-Cu(ClO_4)_2·6H_2O作为非均相催化剂,简单高效地催化靛红-3-亚胺和巯基乙酸进行迈克尔加成-缩合反应,合成了一系列的螺[吲哚-噻唑啉酮]衍生物,收率最高可达99%.另外,发现具有相同官能团的非均相催化剂比均相催化剂表现出更好的催化效果,并进一步探索了介孔分子筛纳米反应器MCM-41孔道结构对该反应的影响.此类催化剂可回收再利用,催化循环6次后仍能得到93%的产率.Herein, Michael addition-condensation of isatin-3-imines with mercaptoacetic acid to afford a new simple and efficient synthesis of spiro[indole-thiazolidine] derivatives in high yield（up to 99%） by using of MCM-41@Schiff base-Cu（ClO4）2·6H_2Oas heterogeneous catalyst is reported. In addition, it is found that heterogeneous catalyst exhibits better activity than homogeneous catalyst in the same functional groups. The effect of the pore structure on mesoporous molecular sieve nanoreactor MCM-41 for this reaction is further explored. Consistent activity of recovered catalyst was found to be almost same up to six cycles in 93% yield.

关 键 词：MCM-41 非均相催化剂 螺[吲哚-噻唑啉酮] 纳米反应器 

分 类 号：O626[理学—有机化学] O643.36[理学—化学]