10μg和5μg乙型肝炎疫苗与乙型肝炎免疫球蛋白联合免疫阻断乙型肝炎病毒母婴传播的效果观察  

Effect of co-administration of 5μg/10μg hepatitis B vaccine and hepatitis B immunoglobulin to interrupt mother-to-infant transmission of hepatitis B virus

作　　者：刘晓霞[1] 杨安华 王晓琼[2] 任坤岭 刘中芹 Liu Xiaoxia;Yang Anhua;Wang Xiaoqiong;Ren Kunling;Liu Zhongqin(Shouguang Maternal and Child Health Hospital,Shouguang 262700,Shandong,China;Shouguang Municipal Center for Disease Control and Preven-tion,Shouguang 262700,Shandong,China)

机构地区：[1]寿光市妇幼保健院,山东寿光262700 [2]寿光市疾病预防控制中心,山东寿光262700

出　　处：《中国疫苗和免疫》2018年第4期393-396,共4页Chinese Journal of Vaccines and Immunization

基　　金：中国肝炎防治基金会-中国乙肝防控科研基金资助课题(YGFK20170009)

摘　　要：目的观察10μg与5μg乙型肝炎（乙肝）疫苗（HepB）与乙肝免疫球蛋白（HBIG）联合免疫阻断乙肝病毒（HBV）母婴传播的效果。方法以山东省寿光市5个街道2005-2015年住院分娩的HBV表面抗原（HBsAg）阳性的母亲及所生儿童（2-12岁）为研究对象,进行问卷调查和采集血清,用ELISA方法检测HBV血清学标志物,分析5μg和10μg HepB与HBIG联合免疫后的HBV母婴传播阻断失败率及影响因素。结果共纳入HBsAg阳性母亲所生儿童696人,其中5μg组245人、10μg组451人。Hep B与HBIG联合免疫后,HBsAg阳性19人,HBV母婴传播阻断失败率为2.73%,其中5μg组、10μg组分别为4.49%、1.77%（χ~2=5.98,P=0.014）。HBVe抗原（HBeAg）阳性母亲所生儿童的阻断失败率以5μg组（20.00%）显著高于10μg组（5.22%）（χ~2=6.85,P=0.009）。结论 10μg HepB的HBV母婴传播阻断效果优于5μg HepB。Objective To observe the effect of either 10μg or 5μg hepatitis B vaccine（ HepB） co-administered with hepatitis B immunoglobulin（ HBIG） for interrupting the mother-to-infant transmission of hepatitis B virus（ HBV）. Methods We selected HBs Ag-positive mothers and their children（ 2-12 years old） from hospitals of five townships of Shouguang city,Shandong province during 2005-2015 and administered a questionnaire and obtained serum samples from the children. We used ELISA to detect serological markers of HBV. We compared failure rates of interrupting mother-to-infant transmission between 10μg and 5μg HepB vaccination combined with HBIG,and determined factors influencing failure to prevent transmission. Results We recruited a total of 696 children whose mothers were HBsAg positive-245 in the 5μg group and 451 in the 10μg group. After co-administration of HepB and HBIG,19 children were HBsAg positive,for a failure rate of 2. 73%,with a 4. 49% failure rate in the 5μg group and a 1. 77% failure rate in the 10μg group（ χ~2= 5. 98,P = 0. 014）. The failure rate for children whose mothers were positive to HBV e antigen（ HBeAg） was higher in the 5μg group（ 20. 00%） than in the 10μg group（ 5. 22%）（ χ~2= 6. 85,P = 0. 009）. Conclusions The effect of 10μg HepB with HBIG was superior to 5μg HepB with HBIG in interrupting mother-to-infant transmission of HBV.

关 键 词：乙型肝炎病毒 母婴传播 乙型肝炎疫苗 乙型肝炎免疫球蛋白 

分 类 号：R186[医药卫生—流行病学]