7-氨基-3-甲氧甲基-3-头孢烯-4-羧酸的合成  

Synthesis of 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic Acid

作　　者：祝占根 陆楠楠 杨彩霞 李啸风[2] 厉梦琳 厉昆 ZHU Zhan-gen;LU Nan-nan;YANG Cai-xia;LI Xiao-feng;LI Meng-lin;LI Kun(Zhejiang Apeloatospo Pharmaceutical Co.,Ltd.,Dongyang 322118,China;Dept.of Chemistry,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江普洛得邦制药有限公司,浙江东阳322118 [2]浙江大学化学系,浙江杭州310027

出　　处：《精细化工中间体》2018年第3期28-30,39,共4页Fine Chemical Intermediates

摘　　要：以碳酸二甲酯为溶剂,BF3/碳酸二甲酯络合物为催化剂,7-氨基-3-乙酰氧甲基-3-头孢烯-4-羧酸(7-ACA)与甲醇进行甲氧基化反应,经三乙胺调酸、过滤、水洗涤、干燥,得到7-氨基-3-甲氧甲基-3-头孢烯-4-羧酸(简称7-AMCA),纯度大于99.0%,收率可达85.0%(n/n)。方法操作简便,溶剂低毒易回收,成本低,产物纯度高,适合工业生产。Using dimethyl carbonate as solvent, BF3/dimethyl carbonate complex as catalyst,7-ACA and methanol as the starting materials, after a process including triethylamine acid adjustment, filtration, water washing, and drying, 7-amino-3-methoxymethyl-3-cefene-4-carboxylic acid （7-AMCA） was obtained with a purity of 99.0% and a molar yield of 85.0%. The process showed the advantages of easy operation, solvent easy recovery, low cost and high purity, which was suitable for industrial production.

关 键 词：7-AMCA 7-ACA 三乙胺 

分 类 号：TQ463.2[化学工程—制药化工]