北京市朝阳区抗结核固定剂量复合剂使用情况  

Application of anti-tuberculosis fixed dose compound in Chaoyang District of Beijing

作　　者：朱岩[1] 闫美凤[2] 张立英 ZHU Yan;YAN Meifeng;ZHANG Liying(Beijing Chaoyang Center for Diseases Prevention and Control,Beijing 100089,China)

机构地区：[1]北京市朝阳区疾病预防控制中心,北京100089 [2]北京市监狱管理局中心医院,北京100054

出　　处：《中国热带医学》2018年第9期942-943,965,共3页China Tropical Medicine

摘　　要：目的分析北京市朝阳区使用抗结核固定剂量复合剂的情况。方法收集2015年1月—12月在北京市朝阳区疾病预防控制中心结核病门诊部277例登记并接受国家免费抗结核治疗的初治活动性肺结核患者使用固定剂量复合剂的临床资料,对其使用情况进行分析。结果 277例使用固定剂量复合剂的患者中,出现不良反应92例(33.21%),因不良反应替换散装药品的患者23例,替换率8.30%,277例初治活动性肺结核转归情况:痰涂片阳性肺结核患者91例,86例治愈(94.51%),91例痰涂片阳性患者抗结核治疗2个月、3个月及6个月痰菌阴转率分别为91.21%、93.41%及94.51%;痰涂片阴性肺结核患者186例,完成疗程174例(93.55%)。结论抗结核固定剂量复合剂为当前国家结核病防治规划中使用的常规药品,值得进一步推广应用。Objective To describe the use of anti-tuberculosis fixed dose compound in Chaoyang District of Beijing.Methods The clinical data of 277 initial treatment pulmonary tuberculosis patients received anti-tuberculosis fixed dose freeof charge in Chaoyang Center for Diseases Prevention and Control from January to December, 2015 were collected andretrospectively analyzed. Results Among 277 patients, 92 cases（33.21%） had adverse reactions, 23 cases（8.30%） changedto bulk drugs for adverse reactions. The long outcomes of 277 cases of initial treatment of active pulmonary tuberculosis： 91 cases of new smear-positive patients, 86 cases of cured patients（94.51%）. The conversion rate of 91 cases of new smearpositive patients treated with fixed dose compound at the end of 2 nd, 3 nd and 6 th month were respectively 91.21%, 93.41%and 94.51%. Among 186 new smear-negative patients, 174 cases completed the courses, accounted for 93.55%.Conclusion As a common drug used in National Tuberculosis Control Program, anti-tuberculosis fixed dose compound isworthy of further promotion and application.

关 键 词：肺结核 抗结核药 固定剂量复合剂 不良反应 

分 类 号：R521[医药卫生—内科学]