基于微流控的细胞操纵方法与应用  

Microfluidics based cell manipulation:Methods and applications

作　　者：孙东[1] 罗涛 SUN Dong;LUO Tao(Department of Biomedical Engineering,City University of Hong Kong,Hong Kong 999077,China)

机构地区：[1]香港城市大学生物医学工程系

出　　处：《科技导报》2018年第16期29-38,共10页Science & Technology Review

基　　金：国家自然科学基金委员会与香港研究局联合科研资助基金项目(N_City U102/15)

摘　　要：微流控技术可实现微量液体的精密操控和多种功能模块的微型化集成,在细胞操纵方面具有精确、高效和低成本等传统手段无法比拟的优点,近些年成为学科交叉领域的研究热点之一。从细胞操纵的原理方法及应用出发,综述了微流控细胞操纵领域的最新研究进展,探讨、总结了各种细胞操纵方法的优缺点,并展望了微流控细胞操纵技术的发展趋势。With the microfluidics,the precise control of micro-liquids and the miniaturized integration of multiple functionalities can be achieved,with incomparable advantages in the cell manipulation in terms of precision,efficiency and cost.Therefore,the microfluidics has become an interdisciplinary research hot spot in recent years.From the perspective of the cell manipulation methods and the corresponding applications,this paper reviews the latest progress in the field of the microfluidic cell manipulation,and discusses the advantages and disadvantages of various cell manipulation methods,and then analyzes the trend of the microfluidics based cell manipulation.

关 键 词：微流控 细胞操纵 细胞分选 细胞富集 单细胞捕获 

分 类 号：Q2-33[生物学—细胞生物学] TN492[电子电信—微电子学与固体电子学]