柚皮素：新一代免疫调节剂  

Research Updates on a Novel Immunomodulator, Naringenin

作　　者：曾文峰[1] 张发云[1] 杜刚军 金凌涛[1,3] 秦蕾[1,4] 董文娟 张超[1] 王洛洋 尹晓哲[1] 张春玲 梁伟[1] ZENG Wen-Feng;ZHANG Fa-Yun;DU Gang-Jun;JIN Ling-Tao;QIN Lei;DONG Wen-Juan;ZHANG Chao;WANG Luo-Yang;YIN Xiao-Zhe;ZHANG Chun-Ling;LIANG Wei(Protein ＆ Peptide Pharmaceutical Laboratory,Institute of Biophysics Chinese Academy of Sciences,Beijing 100101,China;Pharmaceutical College of Henan University,Kaifeng 475004,China;Winship Cancer Institute of Emory University,Atlanta GA 30322,USA;Northwestern University Feinberg School of Medicine,Chicago IL 60611,USA;Ohio State University Medical Center,Columbus OH43210,USA;Department of Chemical Engineering,Tsinghua University,Beijing 100084,China)

机构地区：[1]中国科学院生物物理研究所蛋白质与多肽药物实验室,北京100101 [2]河南大学药学院,开封475004 [3]Winship Cancer Institute of Emory University,Atlanta GA 30322,USA [4]Northwestern University Feinberg School of Medicine,Chicago IL 60611,USA [5]Ohio State University Medical Center,Columbus OH 43210,USA [6]清华大学化工学院,北京100084

出　　处：《生物化学与生物物理进展》2018年第9期915-925,共11页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81503106,81773288,81173633); 国家卫生健康委员会“重大新药创制”科技重大专项(2018ZX09201001-001-004)资助

摘　　要：大量研究表明,植物来源的黄酮类化合物具有广泛的生理活性和药理作用,日常摄取适量的黄酮类化合物能够显著降低许多疾病的发生.柚皮素作为一种自然界分布广泛的黄酮类化合物富含于水果、蔬菜、坚果、咖啡、茶和红酒等日常饮食中,与其他黄酮类化合物相比柚皮素易于胃肠道吸收、生物利用度高且安全剂量大.自2004年起我们对柚皮素调节免疫的分子机制进行了深入系统的研究.本文将重点介绍柚皮素作为一种新型免疫调节剂的研究进展.Lots of researches have indicated wide physiological and pharmacological effects of plant derived natural flavonoids. Daily intake of flavonoids can prevent various diseases. Naringenin is an abundant flavonoid compound in daily food and drinks like fruits, vegetables, nuts, coffee, tea and wine, which can be more easily absorbed by intestines compared to other flavonoids. Since 2004 we have been interested in naringenin due to its superior bioavailability, and then have investigated its immunomodulatory effects with interdisciplinary sciences.The present review will mainly discuss about the recent updates of naringenin as a novel immunomodulator in immune deregulated settings.

关 键 词：柚皮素 TGF-Β 免疫调节剂 炎性细胞因子 肿瘤免疫治疗 

分 类 号：R966[医药卫生—药理学]