透明质酸促进肠道抵抗感染  

Hyaluronic Acids Protects Against Gastric Infection

作　　者：牛沂菲 王海方[1] 付杰 潘莹 刘志华[1,3] NIU Yi-Fei;WANG Hai-Fang;FU Jie;PAN Ying;LIU Zhi-Hua(Key Laboratory of lnfeetion and Immunity of CAS,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Bloomage Freda Biopharm Co.,Ltd,Jinan 250012,China;CAS Center for Excellence in Biomacromolecules,Chinese Academy of Sciences,Beijing 100101,China)

机构地区：[1]中国科学院感染与免疫重点实验室中国科学院生物物理研究所,北京100101 [2]华熙福瑞达生物医药有限公司,济南250012 [3]中国科学院生物大分子科教融合卓越中心,北京100101

出　　处：《生物化学与生物物理进展》2018年第9期981-986,共6页Progress In Biochemistry and Biophysics

基　　金：华熙福瑞达生物医药有限公司资助项目~~

摘　　要：透明质酸是构成细胞外基质的一种重要成分,已有的研究发现,肠道受损后透明质酸的表达上调,促进组织修复.本研究分析了透明质酸在多种肠道感染与肠道炎症模型中的作用.结果显示,口服透明质酸能够提高小鼠对肠道李斯特氏菌、柠檬酸杆菌、肠致病性大肠杆菌感染的控制能力,但对急性肠炎模型没有明显的改善作用.Hyaluronic acid, an important component of extracellular matrix, is up-regulated in intestinal injury to promote wound healing. Here we investigated the roles of hyaluronic acid on different enteritis or intestinal infection models and found that oral administration of hyaluronic acid improved the ability of mice to control the infection of pathogen, including Listeria monocytogenes, Citrobacter rodentium and Enteropathogenic Escherichia coli. These results indicate that hyaluronic acid protects host from gastric infection.

关 键 词：肠道感染 透明质酸 炎症 

分 类 号：Q41[生物学—生理学]