H_3PO_4-Ac_2O催化二苯甲酮肟的Beckmann重排反应研究  

Beckmann Rearrangement of Benzophenone Oxime Catalyzed by Phosphoric Acid-acetic Anhydride

作　　者：章婷 孙晓彤 王鑫尧 潘柳铭 吴慧珍[1] ZHANG Ting;SUN Xiao-tong;WANG Xin-yao;PAN Liu-ming;WU Hui-zhen(College of Biology and Environmental Engineering,Zhejiang Shuren University,Zhejiang Hangzhou 310015,China)

机构地区：[1]浙江树人大学生物与环境工程学院,浙江杭州310015

出　　处：《广州化工》2018年第17期42-44,61,共4页GuangZhou Chemical Industry

摘　　要：为研究不同催化剂对Beckmann重排反应性能的影响,本研究以二苯甲酮为原料制备二苯甲酮肟,以H_3PO_4-Ac_2O(1∶2,V/V)为催化剂利用Beckmann重排制得苯甲酰苯胺。通过单因素试验和正交试验优化得到最佳的实验方案。结果表明10 m L H_3PO_4-Ac_2O,在125℃下反应20 min时,产物收率在92.6%。产物经红外光谱、核磁共振氢谱、高效液相色谱进行分析表征。同时采用高效液相色谱法,测得该化合物的纯度约为97.3%。To study the effect of different catalysts on the Beckmann rearrangement reaction,benzophenone was used as starting material to synthesize the target compound benzanilide by Beckmann rearrangement reactions. Parameters which could influence the Beckmann rearrangement were investigated by single-factor experiment and orthogonal experiment.The optimized synthetic conditions were 10 m L phosphoric acid-acetic anhydride（1 ∶2,V/V） as catalyst at 125 ℃reacted for 20 min. In addition,the reaction product was confirmed by means of infrared spectroscopy and nuclear magnetic resonance. The purity of the compound was about 97. 3% by HPLC.

关 键 词：催化剂 Backmann重排 苯甲酰苯胺 

分 类 号：O69[理学—化学]