质谱技术在内分泌疾病诊疗中的应用  

Application of mass spectrometry in clinical endocrinology

作　　者：赵蓓蓓[1,2] 程雅婷 李维[1,2] 佘旭辉 Zhao Beibe;Cheng fating;Li Wei;She Xuhui(Clinical Mass Spectrometry Center,Guangzhou Kingmed Center for Clinical Laboratory,Guangzhou 510005,China;The Kmgmed Laboratory of Guangzhou Medical University,Guangzhou 510005,China)

机构地区：[1]广州金域医学检验中心临床质谱中心,510005 [2]广州医科大学金域检验学院,510005

出　　处：《中华临床实验室管理电子杂志》2018年第3期129-134,共6页Chinese Journal of Clinical Laboratory Management(Electronic Edition）

摘　　要：激素的检测在内分泌疾病诊疗中扮演着重要角色,质谱技术作为激素检测领域非常有价值的检验技术,因其高特异性、高灵敏度、一次可检测多种化合物等特点,可为疾病的诊断提供更精准、更全面的信息,在改进或改变某些内分泌疾病的临床诊疗和管理路径上,发挥着核心的作用。目前,国内质谱技术在内分泌疾病检验中的应用发展较为缓慢,缺乏全面的阐述报道。本文将围绕目前质谱技术在内分泌疾病诊疗中有突出优势和应用较为成熟的领域:肾上腺疾病中的嗜铬细胞瘤/副神经节瘤、库欣综合征、原发性醛固酮增多症和先天性肾上腺皮质增生症,甲状腺疾病中的甲状腺功能评估,性腺疾病中的雄激素和雌激素的检测,详细阐述质谱技术在这些疾病领域的应用研究进展,剖析质谱技术在内分泌疾病领域应用的优势和挑战,并展望质谱技术在内分泌疾病诊疗中的趋势和方向。The detection of hormone levels plays an important role in the diagnosis and treatment of endocrine diseases. Mass spectrometry, a very valuable tool in the field of hormone detection, can provide more accurate and comprehensive information for the diagnosis of disease because of its high specificity, high sensitivity and the ability to detect multiple compounds at one time. It plays a key role in improving or changing the clinical diagnosis, treatment and management of some endocrine diseases. But now the application of mass spectrometry in endocrine hormone is not common in China, and the comprehensive report is rare. This article will focus on the current mass spectrometry in the diagnosis and treatment of endocrine diseases with prominent advantages and applications of more mature areas including adrenal diseases in pheochromocytoma and paraganglioma, Cushing′s syndrome, primary aldosteronism and congenital adrenal cortical hyperplasia, thyroid disease in thyroid function assessment and detection of androgens and estrogens in glandular disease. We will detailed demonstrate the application of mass spectrometry in the field of these diseases. The advantages and challenges of mass spectrometry in the endocrine diseases are analyzed. The trend and direction of mass spectrometry in the diagnosis and treatment of endocrine diseases are prospected.

关 键 词：质谱技术 内分泌疾病 

分 类 号：R58[医药卫生—内分泌]