118例沙眼衣原体性宫颈炎治疗前后局部免疫状态的变化分析  

Analysis of Local Immunological Changes before and after the Treatment of 118 Cases with Patients with Chlamydia Trachomatis Cervicitis

作　　者：黄泽红[1] 吴华平[1] 董彩霞[1] HUANG Ze-hong;WU Hua-ping;DONG Cai-xia(Department of Gynecology,Huazhou People＇s Hospital,Huazhou,Guangdong Province,525100 China)

机构地区：[1]化州市人民医院妇科,广东化州525100

出　　处：《系统医学》2018年第14期121-123,共3页Systems Medicine

摘　　要：目的探究沙眼衣原体性宫颈炎治疗前后局部免疫状态的变化。方法选取2016年11月—2017年11月在该院进行沙眼衣原体性宫颈炎治疗的118例患者作为患病组,并选取同时期在该院进行健康体检的100例患者作为健康组,对其治疗前后血清白细胞介素-4(IL-4)、血清白细胞介素-8(IL-8)、干扰素-γ(IFN-γ)及肿瘤坏死因子-α(TNF-α)等免疫状态进行检测并比较。结果 118例患者中,有104例治愈,治愈率为88.14%,有110例沙眼衣原体转阴,转阴率为93.22%,且治疗前,患病组患者IL-4水平为(7.59±3.24)pg/m L,显著低于健康组,差异有统计学意义(P<0.05),而IL-8、IFN-γ及TNF-α水平分别为(33.52±5.17)pg/m L、(23.64±5.87)IU/m L及(645.52±35.41)pg/m L,显著高于健康组,差异有统计学意义(P<0.05),经治疗后,患者相应免疫情况均有所好转,且治愈患者相应水平改善程度均显著优于未愈患者,差异有统计学意义(P<0.05)。结论通过对女性患者宫颈等处免疫因子水平进行检测,能够在一定程度上判断沙眼衣原体性宫颈炎的发生及发展情况,有助于对其及时进行治疗及掌握治疗效果,进而对提高患者治疗效果具有重要意义,值得推广。Objective To study the local immunological changes before and after the treatment of patients with chlamydia trachomatis cervicitis.Methods 118 cases of patients with chlamydia trachomatis cervicitis in our hospital from November 2016 to November 2017 were selected,and 100 cases of patients for healthy physical examination in our hospital at the same period were selected as the healthy group,and the IL-4,IL-8,IFN-γ,TNF-α were tested and compared.Results Of 118 cases of patients,104 cases were cured,and the cure rate was 88.14%,of 110 cases with chlamydia trachomatis negative-conversion,and the negative-conversion rate was 93.22%,before treatment,the IL-4 level（7.59±3.24）pg/m L in the disease group was obviously lower than that in the healthy group,the different was stistically significant（P〈0.05）,and the levels of IL-8,IFN-γ,TNF-α were respectively（33.52±5.17） pg/m L,（23.64±5.87）IU/m L,（645.52±35.41） pg/m L,which were obviously higher than those in the healthy group,the different was stistically significant（P〈0.05）,after treatment,the corresponding immune was improved,and the improvement degree of corresponding level in the cured patients was obviously better than that of uncured patients,the different was stistically significant（P〈0.05）.Conclusion The test of immune factor levels such as cervix in females can determine the occurrence and development of chlamydia trachomatis cervicitis,which contributes to timely treatment and mastering the treatment effect,thus improving the treatment effect,and it is worth promotion.

关 键 词：沙眼衣原体性宫颈炎 免疫状态 改变 关联性 

分 类 号：R711.3[医药卫生—妇产科学]