采用电感耦合等离子质谱法检测龟甲及龟甲胶药材中重金属元素的含量  

Detection of the content of heavy metal elements in tortoise shells and tortoise shell glue by using inductively coupled plasma mass spectrometry

作　　者：徐清[1] 李梦[1] 张帆[1] 孟杰亲 罗雪梅 刘春生[1] 杨瑶珺[1] Xu Qing;Li Meng;Zhang Fan;Meng Jieqin;Luo Xuemei;Liu Chunsheng;Yang Yaojun(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《北京中医药大学学报》2018年第8期670-674,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研专项(No.2015468002-2)~~

摘　　要：目的检测龟甲及龟甲胶药材中重金属元素的含量,对重金属元素污染情况进行考察和研究。方法采用电感耦合等离子质谱法(ICP-MS)对市售42批龟甲及混伪品、16批龟甲胶药材进行6种重金属元素(铬、砷、镉、汞、铅、铜)的检测。结果龟甲及混伪品中重金属元素含量平均值从高到低依次为铜(21.96μg/g)、铬(1.70μg/g)、铅(1.28μg/g)、砷(0.29μg/g)、汞(0.15μg/g)、镉(0.09μg/g)。龟甲胶中重金属含量平均值从高到低依次为铜(1.90μg/g)、铬(0.83μg/g)、铅(0.19μg/g)、砷(0.07μg/g)、汞(0.02μg/g)、镉(0.004μg/g)。其中铬和铅元素超过国家限量标准现象比较明显。结论龟甲和龟甲胶药材中重金属含量分布存在一定规律。龟甲胶中的重金属含量明显低于龟甲药材。ICP-MS可以对龟甲及龟甲胶药材进行质量控制和质量评价。Objective To detect the content of heavy metals in medical materials of Guijia（ Tortoise Carapace and Plastron,Testudinis Carapax et Plastrum） and Guijiajiao（ Tortoise Shell Glue,Testudinis Carapacis et Plastri Colla）,and investigate and study the heavy metal pollution of medical materials of Guijia and Guijiajiao. Methods In this study,inductively coupled plasma-mass spectrometry（ ICP-MS） was applied to detect the content of 6 heavy metals [chromium（ Cr）,arsenic（ As）,cadmiu（ Cd）,mercury（ Hg）,lead（ Pb） and copper（ Cu） ]in multiple batches of Guijia and Guijiajiao on sale in the market and their adulterants. Results The results showed that heavy metals in Guijia and Guijiajiao were identified in the following descending order： Cu（ 21. 96 μg/g）,Cr（ 1. 70 μg/g）,Pb（ 1. 28 μg/g）,As（ 0.29 μg/g）,Hg（ 0. 15 μg/g）,Cd（ 0. 09 μg/g）. Among them,the content of Cr and Pb exceeded national limit standard significantly. Conclusion There are certain patterns in the distribution of heavy metals in medical materials of Guijia and Guijiajiao. Heavy metals were significantly less in Guijiajiao than that in Guijia. This study can be a reference for controlling and reviewing the quality of Guijia and Guijiajiao.

关 键 词：龟甲 龟甲胶 电感耦合等离子质谱 重金属元素 

分 类 号：R284.1[医药卫生—中药学]