北芪五加颗粒长期毒性试验研究  

Experimental Study on Long-term Toxicity of Beiqi Wujia Granules

作　　者：赵留涛 吴洪银[1,2,3] 吴冠连 陈五常 徐洪德 袁之润[2,3] 吴春丽 ZHAO Liu-tao;WU Hong-yin;WU Guan-lian;CHEN Wu-chang;XU Hong-de;YUAN Zhi-run;WU Chun-li(College of Pharmacy,Zhengzhou University,Zhengzhou,Henan,450001,China;Shangqiu IGM biological technology CO.,Yucheng,Henan,476300,China;Zhengzhou IGM biological technology CO.,Zhengzhou,Henan,450001,China;Zhengzhou Key Laboratory of New Veterinary Drug Preparation Innovation.,Zhengzhou,Henan,450001,China)

机构地区：[1]郑州大学药学院,河南郑州450001 [2]商丘爱己爱牧生物科技股份有限公司,河南虞城476300 [3]郑州爱己爱牧生物技术有限公司,河南郑州450001 [4]郑州市新型兽药制剂创新重点实验室,河南郑州450001

出　　处：《动物医学进展》2018年第9期58-62,共5页Progress In Veterinary Medicine

基　　金：国家重点研发计划(2017YFD0501401)项目;河南省科技开放合作项目(172106000008);智汇郑州"1125"创业紧缺人才项目

摘　　要：为考察北芪五加颗粒对动物的安全性,采用大鼠进行长期毒性试验。设北芪五加颗粒原料(5、2.5、1.25g/kg)剂量组及空白对照组,给药量分别相当于猪每日临床用量的100、50、25倍;给药28d后停药,各组抽取腹主动脉血进行血液学检测和血液生化指标测定,对心、肝、脾、肺、肾等脏器进行组织病理学检查。结果显示,北芪五加颗粒原料高、中、低剂量组与对照组相比除个别指标外,其余指标差异均无统计学意义(P>0.05),未见与药物有关的病理变化。说明北芪五加颗粒临床应用安全。In order to observe the applied safety of Beiqi Wujia granules, the long-term toxicity experiment was conducted in rats.Three treatment groups （5.0,2.5,1.25 g/kg）of Beiqi Wujia granules and blank con- trol group were set up 10 male and female rats in each group,the dose amount was equivalent to 100,50,25 times of clinical pig dosage. After administration for 28 d drug discontinuance, the abdominal aorta blood samples were collected for determining the hematological and biochemical major indicators.The heart,liv- er,spleen, lung and kidney were performed with the histopathological examination. The results showed that=compared with the control group,there were no significant differences in various indexes except indi- vidual indexes and no obvious pathological lesions related to drug toxicity.The research inferred that Beiqi Wujia granules is safe in clinical application.

关 键 词：北芪五加颗粒 长期毒性 大鼠 

分 类 号：S853.76[农业科学—临床兽医学]