多粘类芽孢杆菌脂肽类抗生素合成与分泌机制研究进展  

Advances in Lipopeptide Antibiotics Synthesis and Secretion Mechanism in Paenibacillus polymyxa

作　　者：汪城墙[1] 戴莉[2] 刘凯[1] 杜秉海[1] 丁延芹[1] Wang Chengqiang;Dai Li;Liu Kai;Du Binghai;Ding Yanqin(College of Life Sciences, Shandong Agricultural University/Shandong Key Laboratory of AgriculturalMicrobiology/National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Taian 271018, China;College of Chemistry and Materials Science,Shandong Agricultural University,Taian 271018,China)

机构地区：[1]山东农业大学生命科学学院/山东省农业微生物重点实验室/土肥资源高效利用国家工程实验室,山东泰安271018 [2]山东农业大学化学与材料科学学院,山东泰安271018

出　　处：《山东农业科学》2018年第9期157-163,共7页Shandong Agricultural Sciences

基　　金：国家重点研发计划项目(2017YFD0200804);国家自然科学基金项目(31700094;31770115;31600090);中国博士后基金项目(2015M582121);山东农业大学博士后基金项目(76474);山东农业大学青年科技创新基金项目(24070)

摘　　要：多粘类芽孢杆菌(Paenibacillus polymyxa)是一种常见的植物根际促生细菌,对植物具有直接或间接生防作用,已在控制农业病害、促进作物生长等方面广泛应用。其可抑制植物病原菌,主要通过产生多粘菌素、杀镰刀菌素等脂肽类抗生素发挥作用。关于多粘类芽孢杆菌的脂肽类抗生素合成和分泌等促生相关分子机制的研究具有重要理论和应用价值。本研究综述了多粘类芽孢杆菌的分子遗传操作体系,多粘菌素和杀镰刀菌素合成基因簇的鉴定、表达调控基因的分析和分泌机制,并从脂肽类抗生素合成和分泌机制角度展望其今后的研究趋势。Paenibacillus polymyxa is a common plant growth-promoting bacterium that have direct or indirect synergistic effects. It has been widely used in controlling agricultural diseases and promoting crop growth. P. polymyxa can inhibit some plant pathogens mainly through the production of polymyxin,fusaricidins and other lipopeptide antibiotics. The study on the molecular mechanisms of the lipopeptide antibiotics production and secretion in P. polymyxa has important theoretical and practical value. In this review,we summarized the molecular genetic system of P. polymyxa,and the gene cluster identification,the analysis of regulation genes and the secretion mechanisms of polymyxin and fusaricidins. At last,we proposed the prospect of the mechanism of lipopeptide antibiotics synthesis and secretion.

关 键 词：多粘类芽孢杆菌 植物根际促生细菌 多粘菌素 杀镰刀菌素 分子机制 外排蛋白 

分 类 号：S476.19[农业科学—农业昆虫与害虫防治]