上海市0～4岁儿童肛门生殖器距离分布队列研究  

Anogenital distance among children aged 0-4 years in Shanghai city: a cohort study

作　　者：夏芮岚 李粉 刘晓敏 梁红[2] 杨芬[2] 纪红蕾[2] 袁伟[2] 苗茂华[2] XIA Rui-lan;LI Fen;LIU Xiao-min(School of Public Health,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学公共卫生学院,上海200032 [2]上海市计划生育科学研究所

出　　处：《中国公共卫生》2018年第9期1193-1197,共5页Chinese Journal of Public Health

基　　金：国家重点研发计划项目(2016YFC1000505);国家自然科学基金海外及港澳学者合作研究基金(21628701);上海市自然基金(16ZR1430100);上海市青年科技英才杨帆计划项目(17YF1416800);国家人口和计划生育委员会计划生育药具重点实验室科技创新导向项目(CX2017-OX)

摘　　要：目的获得上海市0～4岁儿童肛门生殖器距离(AGD)分布,探讨体重和身长/身高对AGD的影响。方法本研究基于2012年4—12月在上海市闵行区妇幼保健院建立的出生队列(S-MBCS),分娩时对1 157名儿童进行AGD测量并收集出生体重等分娩信息,在6、12和48月龄进行随访,并对儿童进行AGD测量和体格测量。结果在1 157名儿童中,出生、6月龄、12月龄和48月龄男童的AGD均数均大于女童;且男童和女童在0～6个月AGD的增长快于6.01～12个月;在多元线性回归模型中,出生体重越重,其AGD越长,男童肛门至阴茎基底背侧的距离(AGD_(AP))(β=3.56,95%CI=2.52～4.61)、男童肛门至阴囊基底部的距离(AGD_(AS))(β=1.30,95%CI=0.40～2.21)、女童肛门至阴蒂的距离(AGD_(AC))(β=2.77,95%CI=1.90～3.63)、女童肛门至阴唇后联合的距离(AGD_(AF))(β=1.23,95%CI=0.55～1.91)差异均具有统计学意义。6、12和48月龄儿童的AGD与体重有关,与身长/身高无关。结论本研究首次报道了上海市0～4岁儿童AGD的纵向数据,证实了AGD具有性别差异,儿童的体重可对AGD产生影响。Objective To examine the distribution of anogenital distance（AGD） among children aged 0-4 years in Shanghai city and to explore the influence of body weight and length/height on AGD. Methods The study was conducted among the participants of a birth cohort established in Shanghai city by Minhang District Maternal and Child Health Hospital（S-MBCS） from April to December, 2012. The delivery information were collected among 1 157 newborns and the AGD and birth weight of the newborns were measured. The newborns were followed up and their AGD and body weight were measured at 6, 12, and 48 months of age. Results For all the newborns, the AGD values of the boys were greater than those of the girls for the measurements at the birth and the ages of 6, 12, and 48 months old. Among the newborns, the increment of AGD from the birth till the age of 6 months were greater than that from the age of 6 months to 12 months. The results of multivariate linear regression demonstrated that the AGD was positively correlated with birth weight among both the boys and the girls, with following significant regression coefficients： β= 3.56（95% confidence interval [95% CI]： 2.52-4.61） for AGD（AP） of boys（from the anus to the cephalad insertion of the penis）, β = 1.30（95% CI： 0.40-2.21） for AGD（AS） of boys（from the anus to the posterior base of the scrotum）, β = 2.77（95% CI：1.90-3.63） for AGD（AC） of the girls（from the anus to the clitoris）, andβ = 1.23（95% CI： 0.55-1.91） for AGD（AF） of girls（from the anus to the posterior convergence of the fourchette）, respectively. The AGD was associated with body weight but not with body length/height for all the newborns at their ages of 6, 12, and 48 months. Conclusion The study reported distributions of AGD among children in Shanghai city longitudinally from their birth to the age of 4 years. The study results confirm gender difference in AGD and birth weight correlates with AGD among the children.

关 键 词：生殖器 儿童 队列研究 出生体重 肛门生殖器距离 

分 类 号：R179[医药卫生—妇幼卫生保健]