泻南补北法对去势雌性大鼠性激素及脂质代谢的影响  

Effects of reducing the south and reinforcing the north method on sex hormones and lipid metabolism of ovariectomized female rats

作　　者：吴宏进[1] 戴薇薇[1] 王利波[1] 张婕 王成龙[1] WU Hong-jin;DAI Wei-wei;WANG Li-bo;ZHANG Jie;WANG Cheng-long(Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《中华中医药杂志》2018年第9期4114-4117,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海市自然科学基金项目(No.16ZR1447300)~~

摘　　要：目的:观察泻南补北法对去势雌性SD大鼠性激素及脂代谢水平的影响,探讨其防治心血管疾病方面的可能作用机制。方法:8周龄雌性SD大鼠随机分为模型组、泻南补北组、戊酸雌二醇组、对照组,对照组给予假手术加正常饲料,其余3组给予去势手术加高脂乳剂。连续给药4周后,取血测雌二醇(E_2)和血脂4项[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)],并检测子宫湿重及子宫内膜厚度。结果:与模型组比较,泻南补北组能够提高去势大鼠E_2、HDL-c水平(P<0.05),降低TC水平(P<0.05),改善子宫内膜状态。结论:泻南补北法能够改善围绝经期性激素及脂质代谢,降低围绝经期的远期并发症。该研究为中医药防治围绝经期综合征动脉粥样硬化提供理论和实验依据。Objective： To observe the effects of reducing the south and reinforcing the north method on sex hormones and lipid metabolism of ovariectomized female rats and explore the possible mechanism of its prevention and treatment of cardiovascular diseases. Methods： A total of 40 female Sprague-Dawley （SD） rats of 8 weeks old were divided randomly into model group, reducing the south and reinforcing the north group, estradiol valerate group and control group. The control group was sham surgery with normal feed, and the other groups were ovariectomized with high fat emulsion feed. After 4 weeks of intragastric administration, estradiol （E2） and four blood lipids （TG, TC, HDL-c and LDL-c） of serum were detected. The wet weight of uterus and thickness of endometrium were also measured. Results： Compared with the model group, reducing the south and reinforcing the north group had obvious effects of increasing the levels of E2, HDL-c （P〈0.05）, reducing the content of TC （P〈0.05）, and improving the state of endometrium. Conclusion： Reducing the south and reinforcing the north method has the effects of improving the sex hormone and lipid metabolism during the climacteric period, reducing the long-term complications of perimenopause. This study could provide theoretical and experimental basis for the prevention and treatment of atherosclerosis in perimenopausal syndrome.

关 键 词：泻南补北法 性激素 脂质代谢 围绝经期 

分 类 号：R285.5[医药卫生—中药学]