补肾益髓胶囊治疗肝肾阴虚复发缓解型多发性硬化临床疗效观察  

Clinical efficacy observation of Bushen Yisui Capsule on relapsing remitting multiple sclerosis with syndrome of deficiency of kidney-liver yin

作　　者：樊永平[1] 陈克龙 尤昱中[1] 王苏[1] 杨涛[1] 万江龙[1] FAN Yong-ping;CHEN Ke-long;YOU Yu-zhong;WANG Su;YANG Tao;WAN Jiang-long(Department of Traditional Chinese Medicine,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;Department of Neurology,Wenzhou Hospital of Traditional Chinese Medicine,Affiliated to Zhejiang Chinese Medicine University,Wenzhou 325000,China)

机构地区：[1]首都医科大学附属北京天坛医院中医科,北京100050 [2]浙江中医药大学附属温州中医院神经内科,温州325000

出　　处：《中华中医药杂志》2018年第9期4220-4223,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81072765;No.81473640;No.81173237)~~

摘　　要：目的:评价补肾益髓胶囊治疗复发缓解型多发性硬化(RRMS)缓解期的临床疗效。方法:采用随机对照双盲法,纳入2011年12月至2014年6月就诊于首都医科大学附属北京天坛医院中医科的RRMS患者60例,中医辨证分型属于肝肾阴虚型,随机分为治疗组和安慰剂组。在西医常规治疗的基础上,治疗组加用补肾益髓胶囊,安慰剂组加用安慰剂治疗,干预时间3个月。对比两组患者治疗前后扩展残疾状态量表(EDSS)评分及中医症状评分,探讨补肾益髓胶囊治疗肝肾阴虚型RRMS患者的疗效。结果:治疗前两组患者EDSS、中医症状评分差异无统计学意义;治疗后,治疗组和安慰剂组EDSS评分、中医症状评分均较治疗前降低(P<0.05,P<0.01),且治疗组优于安慰剂组(P<0.05);治疗组在改善患者酸软无力、急躁易怒、视物模糊、感觉、疼痛及烦热盗汗症状具有显著疗效(P<0.01,P<0.05),且临床显效率显著高于安慰剂组(P<0.01)。结论:补肾益髓胶囊能显著改善RRMS患者缓解期的临床症状,提高患者生活质量,值得临床推广使用。Objective： To observe the clinical efficacy of Bushen Yisui Capsule（BSYSC） on relapsing remitting multiple sclerosis（RRMS） during remission. Methods： The randomized, double-blind, parallel control design was carried out in this study. Sixty RRMS patients during remission were enrolled at Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University during 12, 2011 to 06, 2014. All the patients（treatment group, 30 cases; placebo group, 30 cases） belonged to syndrome of deficiency of kidney-liver yin, and were taking orally prednisone. The treatment group taken with BSYSC for 3 months and the placebo group with placebo instead. The clinical effects were valued by expanded disability status scale（EDSS） and traditional Chinese medicine symptom scores（TCMSS）. Results： The difference of EDSS and TCMSS between two groups before treatment was not significant. Compared with pre-treatment, the EDSS score and TCMSS of treatment group and placebo group decreased significantly（P〈0.05, P〈0.01）, and the treatment group was superior to the placebo group（P〈0.05）. The functions were improved in lassitude, irritability, blurred vision, feeling, pain, night sweat and other symptoms of treatment group（P〈0.01, P〈0.05）, and the dinical effective rate was significantly higher than that of the placebo group（P〈0.01）. Conclusion： The symptoms of RRMS can be alleviated by BSYSC treatment, it can improve the quality of ife, and it＇s worthy of clinical promotion.

关 键 词：肝肾阴虚 多发性硬化 补肾益髓胶囊 中医症状评分 复发缓解型多发性硬化 

分 类 号：R277.7[医药卫生—中医学]