基于跨膜蛋白gp41为作用靶点的抗HIV-1药物研究进展  

Research Progress of Anti HIV-1 Drugs Based on Transmembrane Protein gp41 as a Target

作　　者：康银花[1] 顾觉奋[2] KANG Yin-hua;GU Jue-fen(Editorial Department of Progress in Pharmaceutical Sciences.China Pharmace.tical University,Nanjing 210009,China;School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学<药学进展>编辑部,南京210009 [2]中国药科大学生命科学与技术学院,南京210009

出　　处：《抗感染药学》2018年第7期1105-1111,共7页Anti-infection Pharmacy

摘　　要：高效抗逆转录病毒治疗法(highly active antiretroviral therapy,HAART)是当今抗人免疫缺陷病毒(HIV)感染的主要方法,随着HAART的广泛应用,诸如药物交互作用、不良反应和耐药毒株等问题也相继出现,因此人们致力于其他抗HIV药物的研究。gp41是HIV-1病毒表面的一种包膜糖蛋白,介导了病毒膜和宿主细胞膜间的融合,在HIV-1的侵染过程中起了关键作用。基于gp41为相关靶点的HIV-1融合抑制剂是近年来抗HIV-1药物研究的热点。概述gp41的结构及融膜机制,并对gp41为作用靶点的抗HIV-1药物的研究文献,及其研究进展做了分析。Nowadays, highly active antiretroviral therapy is the main method in anti-human immunodeficiency virus（HIV） infection. However, with the widespread use of HAART, there one after another appear drug interactions, adverse reactions, drug resistant strains, and so on. So people are trying to develop other anti-HIV drugs. Gp41 is an envelope glycoprotein on the surface of HIV-1 virus, the fusion between the viral membrane and the host cell membrane is mediated, and plays a key role in the process of HIV-1 infection. HIV-1 fusion inhibitors using gp41 as a related target,have been the hotspot of anti HIV-1 drug research in recent years. The structure and fusion mechanism of gp41 have been introduced, and the research progresses of anti-HIV-1 drug stargeting gp41 have been summarized. Besides the research progress is also analyzed.

关 键 词：人免疫缺陷病毒 艾滋病 跨膜蛋白gp41 融合抑制剂 

分 类 号：R283.6[医药卫生—中药学]