基于复杂网络分析倪珠英教授治疗小儿鼻鼽病用药规律  

Analysis on Professor NI Zhu-ying's Treatment in Pediatric Rhinitis Based on Complex Network

作　　者：李羚青[1,2] 黄梦雪 刘建忠 刘晓鹰[1,2] 陈瑶 LI Ling-qing;HUANG Meng-xue;LIU Jian-zhong;LIU Xiao-ying;CHEN Yao(Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Wuhan 430061,China;,Hubei Provincial Traditional Chinese Medicine Research Institute,Hubei Wuhan 430061,China;,Hubei University of Traditional Chinese Medicine,Hubei Wuhan 430061,China)

机构地区：[1]湖北省中医院,湖北武汉430061 [2]湖北省中医药研究院,湖北武汉430061 [3]湖北省中医药大学,湖北武汉430061

出　　处：《中医药导报》2018年第17期27-30,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局项目(2004BA721A01Z73);项目名称:全国名老中药专家传承工作室建设项目-倪珠英临床经验;学术思想研究工作室

摘　　要：目的:分析倪珠英教授治疗小儿鼻鼽病的用药规律。方法:将倪珠英教授门诊病例录入结构化临床病例采集系统,选取其中治疗小儿鼻鼽病病例223诊次,用中医传承辅助平台对录入数据进行预处理,再进行用药频次、药物剂量、药类统计,并利用复杂网络系统分析核心药物和常用配伍规律。结果:倪珠英教授治疗小儿感冒病药物频次前10味药:黄芪、白芷、细辛、羌活、防风、炒苍耳子、金银花、鱼腥草、黄芩、辛夷,药类比例按高低顺序依次为:清热药、解表药、补虚药、化痰药、活血化瘀药、理气药、祛风湿药。复杂网络鼻鼽病核心药物:黄芪、白芷、细辛、羌活、防风、炒苍耳子、桔梗、金银花、黄芩、鱼腥草。主要药物配伍:知母、醋龟甲、黄柏,吴茱萸、砂仁,皂角刺、麸炒僵蚕,麸炒枳壳、前胡,蜜麻黄、炒苦杏仁,陈皮、瓜蒌皮、法半夏,乌梅、徐长卿。结论:该方法可以总结倪珠英教授用药规律,能够更客观的整理总结名老中医的经验,为临床用药提供更多参考。Objective： To analyze the medication rule of professor NI＇s treatment for pediatric rhinitis.Methods： Professor NI＇s outpatient cases were entered into a structured clinical case collection system, and 223 cases of the treatment for pediatric rhinitis were selected. The input data were pre-processed by the traditional Chinese Medicine Inheritance assistant platform, and then the frequency, dosage and category of drugs were counted. The regularity of core prescription and traditional Chinese medicine compatibility were analyzed based on the complex network system. Results： The top 10 drugs of Professor NI for treating pediatric rhinitis were：Huangqi（astragalus）, Baizhi（Dahurian angelica）, Xixin（asarum）, Qianghuo（notopterygium）, Fangfeng（saposhnikovia）,Cang＇erzi（xanthium）, Jinyinhua（lonicera）, Yuxingcao（houttuynia）, Huangqin（scutellaria）, and Xinyi（magnolia flower）.The proportion of medicines in the order of high to low were： heat-clearing medicinal, exterior-resolving medicinal, supplement vacuity medicinal, phlegm-transforming medicinal, blood-quickening stasis-transforming medicinal, qi-rectifying medicinal, and wind-damp-dispelling medicinal. The core medicines for rhinitis based on the complex network were： Huangqi, Baizhi, Xixin, Qianghuo, Fangfeng, Cang＇erzi, Jiegeng（platycodon）, Jinyinhua,Huangqin, and Yuxincao. The commonly used drugs for compatibility were： Zhimu（anemarrhena）, Cuguijia（vinegar tortoise plastron）, Huangbai（phellodendron）, Wuzhuyu（evodia）, Sharen（amomum）, Zaojiaoci（gleditsia thorn）, bran fried batryticated silkworm, bran fried hovenia dulcis, Qianhu（peucedanum）, Mimahuang（honey ephedra）, bitter apricot kernel, Chenpi（tangerine peel）, Gualoupi（trichosanthes rind）, Fabanxia（pro formula pinellia）, Wumei（mume）,and Xuchangqing（paniculate cynanchum）. Conclusion： The complex network method can summarize the medication rules of Professor NI＇s treatment, can summarize the experie

关 键 词：倪珠英 中医 小儿鼻鼽病 数据挖掘 用药规律 

分 类 号：R272[医药卫生—中医儿科学]